Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors - Archive ouverte HAL Access content directly
Journal Articles Journal of Natural Products Year : 2020

Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Abstract

Thirteen carneic acids were isolated from the fungal endophyte Phomopsis sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds 1-13 were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC50 values in the 10 to 20 mu M range without cytotoxicity. None inhibited Zika virus NS5 protein.
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Dates and versions

hal-02902217 , version 1 (18-07-2020)

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Laure-Anne Peyrat, Véronique Eparvier, Cecilia Eydoux, Jean-Claude Guillemot, Marc Litaudon, et al.. Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors. Journal of Natural Products, 2020, 83, pp.2330-2336. ⟨10.1021/acs.jnatprod.9b01169⟩. ⟨hal-02902217⟩
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