Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Natural Products Année : 2020

Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Résumé

Thirteen carneic acids were isolated from the fungal endophyte Phomopsis sp. SNB-LAP1-7-32. Their structures were identified by mass spectrometry and extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. Compounds 1-13 were investigated for their antipolymerase activities against DENV polymerase and Zika NS5. Five of them exhibited significant inhibition of dengue polymerase with IC50 values in the 10 to 20 mu M range without cytotoxicity. None inhibited Zika virus NS5 protein.

Domaines

Autre
Fichier principal
Vignette du fichier
Article_dans_template_Revised2.pdf (795.08 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02902217 , version 1 (18-07-2020)

Identifiants

Citer

Laure-Anne Peyrat, Véronique Eparvier, Cecilia Eydoux, Jean-Claude Guillemot, Marc Litaudon, et al.. Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors. Journal of Natural Products, 2020, 83, pp.2330-2336. ⟨10.1021/acs.jnatprod.9b01169⟩. ⟨hal-02902217⟩
50 Consultations
110 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More