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Article Dans Une Revue Tetrahedron Letters Année : 2020

Synthesis and biological activities of new pyrrolocarbazole-imidazobenzimidazole conjugates

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New pyrrolocarbazole-imidazobenzimidazole conjugates were prepared and evaluated for their inhibitory potencies toward Pim-1 kinase, DNA binding and antiproliferative activities against human tumor cell lines. The results demonstrated that conjugation of pyrrolocarbazole Pim inhibitors with imidazobenzimidazole derivatives could enhance the antiproliferative potency of conjugates compared to the derived compounds.
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hal-02901961 , version 1 (15-07-2022)

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Fabrice Anizon, Francis Giraud, Ekaterina Ivanova, Dmitry Kaluzhny, Alexander Shtil, et al.. Synthesis and biological activities of new pyrrolocarbazole-imidazobenzimidazole conjugates. Tetrahedron Letters, 2020, 61 (30), pp.152096. ⟨10.1016/j.tetlet.2020.152096⟩. ⟨hal-02901961⟩
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