Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor
Résumé
A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying substrates, substituents or heating mode it is possible to selectively synthesize indole, indolone (1,5,6,7-tetradihydroindol-4-one) or cinnoline (5,6,7,8-tetrahydrocinnoline) derivatives in moderate to excellent yields.
Domaines
Chimie
Fichier principal
Article_BJOC.pdf (634.46 Ko)
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1860-5397-16-144.pdf (426.89 Ko)
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