Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: A [ 11 C]FLB 457 PET study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue NeuroImage Année : 2009

Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: A [ 11 C]FLB 457 PET study

Ji Hyun Ko
  • Fonction : Auteur
Alain Ptito
  • Fonction : Auteur
Sang Soo Cho
  • Fonction : Auteur
Pablo Rusjan
  • Fonction : Auteur
Sylvain Houle
  • Fonction : Auteur
Antonio P Strafella
  • Fonction : Auteur
  • PersonId : 1074425

Résumé

There is clear evidence that the prefrontal cortex is strongly involved in executive processes and that dopamine can influence performance on working memory tasks. Although, some studies have emphasized the role of striatal dopamine in executive functions, the role played by prefrontal dopamine during executive tasks is unknown. In order to investigate cortical dopamine transmission during executive function, we used D 2-dopamine receptor ligand [ 11 C]FLB 457 PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). During the retrieval with shift task of the MCST, the subjects had to match each test card to one of the reference cards based on a classification rule (color, shape or number) determined by comparing the previously viewed cue card and the current test card. A reduction in [ 11 C]FLB 457 binding potential in the right dorsal anterior cingulate cortex (ACC) was observed when subjects performed the active task compared to the control task. These findings may suggest that right dorsal ACC dopamine neurotransmission increases significantly during the performance of certain executive processes, e.g., conflict monitoring, in keeping with previous evidence from fMRI studies showing ACC activation during similar tasks. These results may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease and schizophrenia.
Fichier principal
Vignette du fichier
Ko et al. - 2009 - Increased dopamine release in the right anterior c.pdf (363.13 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02890858 , version 1 (06-07-2020)

Identifiants

Citer

Ji Hyun Ko, Alain Ptito, Oury Monchi, Sang Soo Cho, Thilo van Eimeren, et al.. Increased dopamine release in the right anterior cingulate cortex during the performance of a sorting task: A [ 11 C]FLB 457 PET study. NeuroImage, 2009, 46, pp.516 - 521. ⟨10.1016/j.neuroimage.2009.02.031⟩. ⟨hal-02890858⟩

Collections

HCL
20 Consultations
105 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More