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Article Dans Une Revue Digestive and Liver Disease Année : 2020

Management of T1 colorectal cancers detected at screening colonoscopy A study from the French national screening programme

Résumé

Aim : The main aim of this study was to examine the management strategies that were used and to determine the outcomes (survival and recurrence rate) of screen-detected T1-CRC.Methods : Medical records from 207 patients with T1-CRC diagnosed through the French national screening programme in one district from 2003 to 2015 were analysed. The 5-year overall, CRC-specific and CRC-free survival were calculated for the whole cohort and for the3 groups treated by endoscopic resection (ER) alone, ER followed by subsequent surgery (ERSS), and primary surgery (PS).Results : Of the 207 patients, 81 (39%) underwent PS, and 126 (61%) underwent primary ER, of whom 82 (64%) underwent subsequent surgery. The 5-year overall and cancer-specific survival rates were 95.5% (95% CI, 90.8; 97.9) and 98.8% (95% CI, 95.4; 99.7%), respectively.Long-term cancer-specific mortality and recurrence crude rates were 2.4% and 5.6%, respectively. The 5-year CRC-free survival rate was 96.1% (95% CI, 91.8; 98.1%) and did not differ among the 3 groups (ER alone, ERSS and PS).Conclusion : This study demonstrates the good prognosis of screen-detected T1-CRC, regardless of the treatment strategy used. But, there is a room to improve the screening programme quality with regard to the management of screen-detected CRC.
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Dates et versions

hal-02890721 , version 1 (10-07-2020)

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Thomas Grainville, Jean-François Bretagne, Christine Piette, Chloé Rousseau, Martin Bordet, et al.. Management of T1 colorectal cancers detected at screening colonoscopy A study from the French national screening programme. Digestive and Liver Disease, 2020, 52 (8), pp.909-917. ⟨10.1016/j.dld.2020.04.022⟩. ⟨hal-02890721⟩
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