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Journal Articles Coordination Chemistry Reviews Year : 2012

Methods and techniques to study the bioinorganic chemistry of metal–peptide complexes linked to neurodegenerative diseases

Peter Faller
  • Function : Author
  • PersonId : 1017153
Pierre Dorlet
Petra Hellwig
Yannick Coppel
Bruno Alies
  • Function : Author
  • PersonId : 1088738

Abstract

This article provides a review about the most common techniques used to study the interaction of metal ions with amyloidogenic peptides. It is addressed to researchers, who want to know what kind of techniques exists, the information which can be obtained, their advantages, limits and the demands concerning sample preparation etc. It is not addressed to specialists of these techniques as the physical principles of the techniques are nor given. First, a general overview is given about sample preparation and treatment, with focus on the metal ions Zn(II), Cu(I/II) and Fe(II/III) and the peptides amyloid-β (but also α-synuclein, prion etc.). Then the methods NMR, EPR, electrochemistry, optical spectroscopy, isothermal titration calorimetry, FTIR, X-ray absorption and mass spectrometry are treated.

Dates and versions

hal-02888019 , version 1 (02-07-2020)

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Peter Faller, Christelle Hureau, Pierre Dorlet, Petra Hellwig, Yannick Coppel, et al.. Methods and techniques to study the bioinorganic chemistry of metal–peptide complexes linked to neurodegenerative diseases. Coordination Chemistry Reviews, 2012, 256 (19-20), pp.2381-2396. ⟨10.1016/j.ccr.2012.03.015⟩. ⟨hal-02888019⟩
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