Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neuron Année : 2015

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.

Sébastien Sultan
  • Fonction : Auteur
Liyi Li
  • Fonction : Auteur
Jonathan Moss
  • Fonction : Auteur
Francesco Petrelli
  • Fonction : Auteur
Frédéric Cassé
Elias Gebara
  • Fonction : Auteur
Jan Lopatar
  • Fonction : Auteur
Paola Bezzi
Josef Bischofberger
  • Fonction : Auteur
Nicolas Toni

Résumé

Adult neurogenesis is regulated by the neurogenic niche, through mechanisms that remain poorly defined. Here, we investigated whether niche-constituting astrocytes influence the maturation of adult-born hippocampal neurons using two independent transgenic approaches to block vesicular release from astrocytes. In these models, adult-born neurons but not mature neurons showed reduced glutamatergic synaptic input and dendritic spine density that was accompanied with lower functional integration and cell survival. By taking advantage of the mosaic expression of transgenes in astrocytes, we found that spine density was reduced exclusively in segments intersecting blocked astrocytes, revealing an extrinsic, local control of spine formation. Defects in NMDA receptor (NMDAR)-mediated synaptic transmission and dendrite maturation were partially restored by exogenous D-serine, whose extracellular level was decreased in transgenic models. Together, these results reveal a critical role for adult astrocytes in local dendritic spine maturation, which is necessary for the NMDAR-dependent functional integration of newborn neurons.

Dates et versions

hal-02882611 , version 1 (26-06-2020)

Identifiants

Citer

Sébastien Sultan, Liyi Li, Jonathan Moss, Francesco Petrelli, Frédéric Cassé, et al.. Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.. Neuron, 2015, 88 (5), pp.957-972. ⟨10.1016/j.neuron.2015.10.037⟩. ⟨hal-02882611⟩

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