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Article Dans Une Revue Scientific Reports Année : 2018

Occupational radiation exposure and glaucoma and macular degeneration in the US radiologic technologists

M.P. Little
  • Fonction : Auteur
C.M. Kitahara
  • Fonction : Auteur
E.K. Cahoon
  • Fonction : Auteur
R. Velazquez-Kronen
  • Fonction : Auteur
M.M. Doody
  • Fonction : Auteur
D. Borrego
  • Fonction : Auteur
J.S. Miller
  • Fonction : Auteur
S.L. Simon
  • Fonction : Auteur
D.L. Preston
  • Fonction : Auteur
M.S. Linet
  • Fonction : Auteur
N. Hamada
  • Fonction : Auteur

Résumé

There are well-documented associations of glaucoma with high-dose radiation exposure, but only a single study suggesting risk of glaucoma, and less conclusively macular degeneration, associated with moderate-dose exposure. We assessed risk of glaucoma and macular degeneration associated with occupational eye-lens radiation dose, using participants from the US Radiologic Technologists Study, followed from the date of surveys in 1994-1998, 2003-2005 to the earliest of diagnosis of glaucoma or macular degeneration, cancer other than non-melanoma skin cancer, or date of last survey (2012-2014). We excluded those with baseline disease or previous radiotherapy history. Cox proportional hazards models with age as timescale were used. There were 1631 cases of newly self-reported doctor-diagnosed cases of glaucoma and 1331 of macular degeneration among 69,568 and 69,969 eligible subjects, respectively. Estimated mean cumulative eye-lens absorbed dose from occupational radiation exposures was 0.058 Gy. The excess relative risk/Gy for glaucoma was -0.57 (95% CI -1.46, 0.60, p = 0.304) and for macular degeneration was 0.32 (95% CI -0.32, 1.27, p = 0.381), suggesting that there is no appreciable risk for either endpoint associated with low-dose and low dose-rate radiation exposure. Since this is the first examination of glaucoma and macular degeneration associated with low-dose radiation exposure, this result needs to be replicated in other low-dose studies.
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hal-02881809 , version 1 (20-07-2020)

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M.P. Little, C.M. Kitahara, E.K. Cahoon, M.-O. Bernier, R. Velazquez-Kronen, et al.. Occupational radiation exposure and glaucoma and macular degeneration in the US radiologic technologists. Scientific Reports, 2018, 8 (1), pp.10481. ⟨10.1038/s41598-018-28620-6⟩. ⟨hal-02881809⟩
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