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Article Dans Une Revue Muscle Nerve Année : 2014

Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X-linked myotubular myopathy

A. Sarwal
  • Fonction : Auteur
M. S. Cartwright
  • Fonction : Auteur
F. O. Walker
  • Fonction : Auteur
A. H. Beggs
  • Fonction : Auteur
M. K. Childers
  • Fonction : Auteur

Résumé

INTRODUCTION: We tested the feasibility of using neuromuscular ultrasound for non-invasive real-time assessment of diaphragmatic structure and function in a canine model of X-linked myotubular myopathy (XLMTM). METHODS: Ultrasound images in 3 dogs [wild-type (WT), n = 1; XLMTM untreated, n = 1; XLMTM post-AAV8-mediated MTM1 gene replacement, n = 1] were analyzed for diaphragm thickness, change in thickness with respiration, muscle echogenicity, and diaphragm excursion amplitude during spontaneous breathing. RESULTS: Quantitative parameters of diaphragm structure were different among the animals. WT diaphragm was thicker and less echogenic than the XLMTM control, whereas the diaphragm measurements of the MTM1-treated XLMTM dog were comparable to those of the WT dog. CONCLUSIONS: This pilot study demonstrates the feasibility of using ultrasound for quantitative assessment of the diaphragm in a canine model. In the future, ultrasonography may replace invasive measures of diaphragm function in canine models and in humans for non-invasive respiratory monitoring and evaluation of neuromuscular disease. Muscle Nerve 50: 607-609, 2014.

Dates et versions

hal-02881170 , version 1 (25-06-2020)

Identifiants

Citer

A. Sarwal, M. S. Cartwright, F. O. Walker, E. Mitchell, A. Buj-Bello, et al.. Ultrasound assessment of the diaphragm: Preliminary study of a canine model of X-linked myotubular myopathy. Muscle Nerve, 2014, 50 (4), pp.607-9. ⟨10.1002/mus.24294⟩. ⟨hal-02881170⟩
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