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Article Dans Une Revue Chemical Communications Année : 2018

Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

Résumé

We studied the effect of subtle changes in side-chain chemistry and labelling with near infrared fluorophores of nanogels (NGs) prepared from thiolated poly(glycidol) on in vivo biodistribution in mice bearing human breast tumor xenografts. The stability and amphiphilic character of the side chain as well as labelling clearly influenced tumor targeting and overall biodistribution.
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Dates et versions

hal-02872393 , version 1 (17-06-2020)

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Ilona Zilkowski, Ioanna Theodorou, Krystyna Albrecht, Frederic Duconge, Jürgen Groll. Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels. Chemical Communications, 2018, 54 (83), pp.11777-11780. ⟨10.1039/c8cc05627g⟩. ⟨hal-02872393⟩
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