Article Dans Une Revue Frontiers in Physiology Année : 2020

Exercise-Released Myokines in the Control of Energy Metabolism

Résumé

Physical activity reduces cardiometabolic risk, while physical inactivity increases chronic diseases risk. This led to the idea that exercise-induced muscle contraction contributes to metabolic regulation and health. It is now well established that skeletal muscle, through the release of endocrine factors, i.e., so-called myokines, crosstalk with metabolic organs such as adipose tissue, liver and pancreas. Recent advances suggested that a number of myokines are able to modulate adipose tissue metabolism and thermogenic activity, liver endogenous glucose production and β-cell insulin secretion. This novel paradigm offers a compelling hypothesis and molecular basis to explain the link between physical inactivity and chronic diseases. Herein, we review major findings and recent advances linking exercise, myokines secretion and inter-organ crosstalk. Identifying the molecular mediators linking physical activity to metabolic health could open the path toward novel therapeutic targets in metabolic diseases.

Fichier principal
Vignette du fichier
efe8e440066f1daf70ef83ed21ef0857456c.pdf (444.83 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence
Loading...

Dates et versions

hal-02868660 , version 1 (15-06-2020)

Licence

Identifiants

Citer

Claire Laurens, Audrey Bergouignan, Cédric Moro. Exercise-Released Myokines in the Control of Energy Metabolism. Frontiers in Physiology, 2020, 11, pp.91. ⟨10.3389/fphys.2020.00091⟩. ⟨hal-02868660⟩
93 Consultations
285 Téléchargements

Altmetric

Partager

  • More