Influence of the substituted b-cyclodextrins by amino groups on the complexation of antifungal drug - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of the Tunisian Chemical Society Année : 2017

Influence of the substituted b-cyclodextrins by amino groups on the complexation of antifungal drug

Résumé

The selective functionalization on the primary face of b-cyclodextrin with amino groups is described. The inclusion complexation of griseofuvin (GSV) molecules by b-cyclodextrin and its synthesized amino derivatives has been elucidated. The stability constants of the complexes of 1:1 stoichiometry (K11) have been evaluated from 1H chemical shift changes of griseofuvin protons. Mono- and per-amino substuted β‑cyclodextrin showed an increase of inclusion binding ability for griseofulvin guest. The fully amino substituted b-cyclodextrin at the primary face shows the strongest complexation ability towards griseofulvin molecules. A simple thermodynamic theory of the electrostatic contribution to the complexation is presented.
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Dates et versions

hal-02842415 , version 1 (13-06-2020)

Identifiants

  • HAL Id : hal-02842415 , version 1

Citer

Ines Béjaoui, Mondher Baâzaoui, Yves Chevalier, Noureddine Amdouni, Rafik Kalfat, et al.. Influence of the substituted b-cyclodextrins by amino groups on the complexation of antifungal drug. Journal of the Tunisian Chemical Society, 2017, 19, pp.178-186. ⟨hal-02842415⟩
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