Influence of the substituted b-cyclodextrins by amino groups on the complexation of antifungal drug
Résumé
The selective functionalization on the primary face of b-cyclodextrin with amino groups is described. The inclusion complexation of griseofuvin (GSV) molecules by b-cyclodextrin and its synthesized amino derivatives has been elucidated. The stability constants of the complexes of 1:1 stoichiometry (K11) have been evaluated from 1H chemical shift changes of griseofuvin protons. Mono- and per-amino substuted β‑cyclodextrin showed an increase of inclusion binding ability for griseofulvin guest. The fully amino substituted b-cyclodextrin at the primary face shows the strongest complexation ability towards griseofulvin molecules. A simple thermodynamic theory of the electrostatic contribution to the complexation is presented.