The method of the invention regulates operating parameters comprising at least the average core temperature (Tm) and the axial offset (AO), the method comprising the following steps: - generating a vector (Us) of values of nuclear-reactor commands with a supervisor (31) that implements a predictive control algorithm; - generating a vector (uK) of corrective values for correcting the nuclear-reactor commands with a regulator (33) that implements a gain-scheduling control algorithm; - generating a vector (U) of corrected values of the nuclear-reactor commands, using the vector (Us) of the values of the commands, i.e. the vector generated by the supervisor (31), and the vector (uK) of the corrective values for correcting the commands, i.e. the vector generated by the regulator (33); - regulating the operating parameters of the nuclear reactor, by controlling actuators using the vector (U) of the corrected values of the commands.