Parkinson's disease polygenic risk score is not associated with impulse control disorders: A longitudinal study
J. Ihle
(1, 2, 3, 4)
,
Samir Bekadar
(4, 3, 2, 1)
,
S. Sambin
(4, 3, 2, 1)
,
Olivier J. Rascol
(5, 4, 6, 2)
,
Clemens R. Scherzer
(7, 8)
,
Jean Christophe Corvol
(4, 3, 2, 1)
,
Alexis Elbaz
(9, 10)
,
Marie Vidailhet
(1)
,
Alexis Brice
(1)
,
Fanny Artaud
(9, 11)
,
Frédéric Bourdain
(12)
,
Jean Philippe A. Brandel
(13)
,
Pascal Derkinderen
(14)
,
Franck Durif
(15, 2)
,
Richard M. Levy
(16)
,
Fernando Pico
(17)
,
Olivier Rascol
(5)
,
Anne Marie Bonnet
(1)
,
Cécilia Bonnet
(1)
,
Christine Brefel-Courbon
(5)
,
Florence Cormier-Dequaire
(1)
,
Bertrand Degos
(1)
,
Bérengère Debilly
(15)
,
Monique Galitsky
(5)
,
David Grabli
(1)
,
Andréas Hartmann
(1)
,
Stephan Klebe
(1)
,
Julia Kraemmer
(1)
,
Lucette Lacomblez
(1)
,
Sara Leder
(1)
,
Graziella Mangone
(1, 4, 3, 2)
,
Louise Laure Mariani
(1, 4, 3, 2)
,
Ana Raquel Marques
(15)
,
Valérie Mesnage
(16)
,
Julia Muellner
(1)
,
Fabienne Ory-Magne
(5)
,
Violaine Planté-Bordeneuve
(18)
,
Emmanuel Roze
(1)
,
Fazia Mélissa Tir
(17)
,
Hana You
(1)
,
Eve Benchetrit
(1)
,
Julie Socha
(1)
,
Fanny Pineau
(1)
,
Tiphaine Vidal
(15)
,
Elsa Pomies
(5)
,
Virginie Bayet
(5)
,
Suzanne Lesage
(4)
,
Khadija Tahiri
(4)
,
Hélène Bertrand
(4)
,
Alain Mallet
(1)
,
Coralie Villeret
(19)
,
Merry Mazmanian
(1)
,
Hakima Manseur
(1)
,
Mostafa Hajji
(1)
,
Benjamin Le Toullec
(1)
,
Vanessa Brochard
(1)
,
Monica Roy
(14)
,
Isabelle Rieu
(15)
,
Stephane Bernard
(15)
,
Antoine Faurie-Grepon
(5)
1
CHU Pitié-Salpêtrière [AP-HP]
2 NS-Park/FCRIN Network
3 CNRS - Centre National de la Recherche Scientifique
4 INSERM - Institut National de la Santé et de la Recherche Médicale
5 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
6 CIC 1436 - Centre d'investigation clinique de Toulouse
7 BWH - Brigham & Women’s Hospital [Boston]
8 HMS - Harvard Medical School [Boston]
9 CESP - Centre de recherche en épidémiologie et santé des populations
10 UP11 UFR Médecine - Université Paris-Sud - Paris 11 - Faculté de médecine
11 UP11 - Université Paris-Sud - Paris 11
12 Hôpital Foch [Suresnes]
13 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
14 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
15 CHU Clermont-Ferrand
16 CHU Saint-Antoine [AP-HP]
17 CHV - Centre Hospitalier de Versailles André Mignot
18 Hôpital Henri Mondor
19 AP-HP - Hopital Saint-Louis [AP-HP]
2 NS-Park/FCRIN Network
3 CNRS - Centre National de la Recherche Scientifique
4 INSERM - Institut National de la Santé et de la Recherche Médicale
5 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
6 CIC 1436 - Centre d'investigation clinique de Toulouse
7 BWH - Brigham & Women’s Hospital [Boston]
8 HMS - Harvard Medical School [Boston]
9 CESP - Centre de recherche en épidémiologie et santé des populations
10 UP11 UFR Médecine - Université Paris-Sud - Paris 11 - Faculté de médecine
11 UP11 - Université Paris-Sud - Paris 11
12 Hôpital Foch [Suresnes]
13 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
14 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
15 CHU Clermont-Ferrand
16 CHU Saint-Antoine [AP-HP]
17 CHV - Centre Hospitalier de Versailles André Mignot
18 Hôpital Henri Mondor
19 AP-HP - Hopital Saint-Louis [AP-HP]
Alexis Elbaz
- Fonction : Auteur
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- IdHAL : elbaz-alexis
- ORCID : 0000-0001-9724-5490
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Marie Vidailhet
- Fonction : Auteur
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Pascal Derkinderen
- Fonction : Auteur
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Olivier Rascol
- Fonction : Auteur
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Christine Brefel-Courbon
- Fonction : Auteur
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David Grabli
- Fonction : Auteur
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Graziella Mangone
- Fonction : Auteur
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- ORCID : 0000-0002-2847-3067
Louise Laure Mariani
- Fonction : Auteur
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- IdHAL : louise-laure-mariani-halid
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- IdRef : 249283646
Ana Raquel Marques
- Fonction : Auteur
- PersonId : 743222
- IdHAL : ana-marques
- ORCID : 0000-0003-2428-4899
- IdRef : 130036633
Fabienne Ory-Magne
- Fonction : Auteur
- PersonId : 988022
- ORCID : 0000-0001-6179-4500
- IdRef : 061282650
Emmanuel Roze
- Fonction : Auteur
- PersonId : 758800
- ORCID : 0000-0002-7404-591X
Fazia Mélissa Tir
- Fonction : Auteur
- PersonId : 1148633
- ORCID : 0000-0001-9147-5519
- IdRef : 091996406
Résumé
Objective: To examine the relationship between a Parkinson's disease (PD) polygenic risk score (PRS) and impulse control disorders (ICDs) in PD. Background: Genome wide association studies (GWAS) have brought forth a PRS associated with increased risk of PD and younger disease onset. ICDs are frequent adverse effects of dopaminergic drugs and are also more frequent in patients with younger disease onset. It is unknown whether ICDs and PD share genetic susceptibility. Methods: We used data from a multicenter longitudinal cohort of PD patients with annual visits up to 6 years (DIG-PD). At each visit ICDs, defined as compulsive gambling, buying, eating, or sexual behavior were evaluated by movement disorders specialists. We genotyped DNAs using the Megachip assay (Illumina) and calculated a weighted PRS based on 90 SNPs associated with PD. We estimated the association between PRS and prevalence of ICDs at each visit using Poisson generalized estimating equations, adjusted for dopaminergic treatment and other known risk factors for ICDs. Results: Of 403 patients, 185 developed ICDs. Patients with younger age at onset had a higher prevalence of ICDs (p < 0.001) as well as higher PRS values (p = 0.06). At baseline, there was no association between the PRS and ICDs (overall, p = 0.84). The prevalence of ICDs increased over time similarly across the quartiles of the PRS (overall, p = 0.88; DA users, p = 0.99). Conclusion: Despite younger disease onset being associated with both higher PRS and ICD prevalence, our findings are not in favor of common susceptibility genes for PD and ICDs.