Efficient C-3 reductive alkylation of 4-hydroxycoumarin by dehydrogenative oxidation of benzylic alcohols through ruthenium catalysis - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue New Journal of Chemistry Année : 2014

Efficient C-3 reductive alkylation of 4-hydroxycoumarin by dehydrogenative oxidation of benzylic alcohols through ruthenium catalysis

Résumé

A practical route to prepare 4-hydroxycoumarin derivatives functionalized at the C-3 position is described through a catalytic coupling reaction between 4-hydroxycoumarin and a series of substituted benzylic alcohols. The reaction is conducted in the presence of tris(triphenylphosphine)ruthenium(II) dichloride (5 mol%), KOH (0.2 eq.) in (tert)amyl alcohol under microwave irradiation at 140 degrees C for 2 hours.
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hal-02639455 , version 1 (28-05-2020)

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A. Montagut-Romans, M. Boulven, M. Lemaire, Florence Popowycz. Efficient C-3 reductive alkylation of 4-hydroxycoumarin by dehydrogenative oxidation of benzylic alcohols through ruthenium catalysis. New Journal of Chemistry, 2014, 38 (4), pp.1794-1801. ⟨10.1039/c3nj01517c⟩. ⟨hal-02639455⟩
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