Marine sponges are prolific producers of physiologically active secondary metabolites [1, 2]. The chemical exploration of fatty acids derived from of marine organisms is a vital research area [3,4,5]. Fatty acids and lipids obtained from marine sources display unique molecular diversity, including saturated, mono-, di-, and polyunsaturated, branched, halogenated, hydroxylated, methoxylated, epoxide, and non-methylene-interrupted structure [6]. Marine fatty acids exhibit a variety of bioactivities, including antifungal, antibacterial, antimalarial [7], and anticancer [8]. Among the marketed eight marine-derived drugs, the ethyl esters of several omega-3 fatty acids from fish oils, in particular, ethyl esters of the major constituents eicosapentaenoic acid and docosahexaenoic acid, are approved as anti-hypertriglyceridemia and antibacterial drugs [9,10,11].