Non-invasive assessment of oxidative stress in preterm infants - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Free Radical Biology and Medicine Année : 2019

Non-invasive assessment of oxidative stress in preterm infants

Résumé

Preterm newborns have an immature antioxidant defense system and are especially susceptible to oxidative stress. Resuscitation, mechanical ventilation, intermittent hypoxia and apneic episodes require frequently oxygen supplementation which leads to oxidative stress in preterm newborns. The consequences of oxidative damage are increased short and long-term morbidities, neurodevelopmental impairment and increased mortality. Oxidative stress biomarkers are determined in blood samples from preterm children during their stay in neonatal intensive care units especially for research purposes. However, there is a tendency towards reducing invasive and painful techniques in the NICU (Neonatal Intensive Care Unit) and avoiding excessive blood extractions procedures. In this paper, it has been described some studies that employed non-invasive samples to determine oxidative stress biomarkers form preterm infants in order to perform a close monitoring biomarker with a significant greater predictive value. Among these methods we describe a previously developed and validated high-performance liquid chromatography tandem mass spectrometry method that allow to accurately determine the most reliable biomarkers in biofluids, which are non-invasively and painlessly obtained.
Fichier principal
Vignette du fichier
Bautista et al. FRBM 2019, 142, 79-81_HAL.pdf (436.98 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02617362 , version 1 (02-06-2021)

Identifiants

Citer

Carmen Peña-Bautista, Thierry Durand, Claire Vigor, Camille Oger, Jean-Marie Galano, et al.. Non-invasive assessment of oxidative stress in preterm infants. Free Radical Biology and Medicine, 2019, 142, pp.73-81. ⟨10.1016/j.freeradbiomed.2019.02.019⟩. ⟨hal-02617362⟩
23 Consultations
279 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More