Sporochartines A-E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Marine Science Année : 2017

Sporochartines A-E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge

Résumé

Four new sporochartines B-E were isolated from the marine fungus Hypoxylon monticulosum CLL-205, isolated from a sponge belonging to the Sphaerocladina order and collected in Tahiti coast. Sporochartine A (1), the first representative of this family was previously isolated from the same fungus. The structures of sporochartines B-E were elucidated using 1D and 2D NMR, HRMS and IR data. Their configurations were established according to ROE correlations and comparison with the absolute configuration of sporochartine A (1) previously obtained from X-ray analysis. Sporochartines A-D (2-4) may be derived from endo Diels-Alderase type catalysis and sporochartine E (5) from an exo Diels-Alderase catalysis. The spatial conformation of sporochartines drastically influences the results of the cytotoxic bioassay against HCT-116, PC-3 and MCF-7 human cancer cell lines.
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hal-02577590 , version 1 (14-05-2020)

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Charlotte Leman-Loubière, Géraldine Le Goff, Cécile Debitus, Jamal Ouazzani. Sporochartines A-E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge. Frontiers in Marine Science, 2017, 4, pp.UNSP 399. ⟨10.3389/fmars.2017.00399⟩. ⟨hal-02577590⟩
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