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Journal Articles Journal de Neuroradiologie / Journal of Neuroradiology Year : 2020

New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions

Stephane Kremer (1) , Salem Hannoun (2) , Fabrice Bonneville (3, 4) , Francoise Durand-Dubief (5) , Thomas Tourdias (6) , Christian Barillot (7, 8) , Charles Guttmann (8) , Sandra Vukusic (5) , Vincent Dousset (6) , Francois Cotton (9, 10, 11) , R. Ameli (12) , René Anxionnat (13) , Bertrand Audoin (14) , Arnaud Attye (15) , Elise Bannier (7) , Douraied Ben Salem (16) , Marie-Paule Boncoeur-Martel (17) , Gildas Bonhomme (18) , Claire Boutet (19) , Jean-Christophe Brisset (11) , Frédéric Cervenansky (10) , Béatrice Claise (20) , Olivier Commowick (7) , Jean-Marc Constans (21) , Pascal Dardel (18) , Hubert Desal (22) , Jean-Christophe Ferré (7) , Alina Gaultier (22) , E. Gerardin (23) , T. Glattard (24) , Sylvie Grand (25) , T. Grenier (24) , Rémy Guillevin (26) , A. Krainik (25) , S. Lion (9) , Nicolas Menjot de Champfleur (27) , Lydiane Mondot (28) , Olivier Outteryck (29) , Nadya Pyatigorskaya (30) , Jean-Pierre Pruvo (29) , Sylvain Rabaste (9) , Jean-Philippe Ranjeva (31) , Jean-Amédée Roch (9) , Jean-Claude Sadik (32) , Dominic Sappey-Marinier (33) , Julien Savatovsky (18) , Jean-Yves Tanguy (34) , Ayman Tourbah (35) , Bruno Brochet (36) , Romain Casey (36) , Jerome de Seze (37) , Pascal Douek (38) , F. Guillemin (39) , David A. Laplaud (22) , Christine Lebrun-Frenay (28) , Lucilla Mansuy (40) , Thibault Moreau (41) , Javier Olaiz (33) , Jean Pelletier (42) , Claire Rigaud-Bully (43) , Bruno Stankoff (44) , Marc Debouverie (45) , Gilles Edan (7) , Jonathan Ciron (46) , Catherine Lubetzki (30) , Patrick Vermersch (29) , Pierre Labauge (47) , Gilles Defer (23) , Eric Berger (48) , Pierre Clavelou (49) , O. Gout (32) , Eric Thouvenot (50) , Olivier Heinzlef (51) , Abdullatif Al-Khedr (21) , Bertrand Bourre (52) , Olivier Casez (25) , Philippe Cabre (53) , Alexis Montcuquet (54) , Alain Créange (55) , Jean-Philippe Camdessanché (19) , Serge Bakchine (56) , A. Maurousset (57) , Ivania Patry (58) , Thomas de Broucker (59) , Corinne Pottier (60) , Jean-Philippe Neau (26) , Céline Labeyrie (61) , Chantal Nifle (62)
1 Hôpital de Hautepierre [Strasbourg]
2 AUBMC - Nehme and Therese Tohme Multiple Sclerosis Center [Beyrouth, Liban]
3 Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse]
4 ToNIC - Toulouse NeuroImaging Center
5 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
6 U1215 Inserm - UB - Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale
7 Empenn - Neuroimagerie: méthodes et applications
8 Center for Neurological Imaging
9 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
10 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
11 OFSEP - Observatoire Français de la Sclérose En Plaques [Lyon]
12 Service de neuroradiologie [Lyon]
13 Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy]
14 Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM]
15 Service de neuroradiologie [Grenoble]
16 LaTIM - Laboratoire de Traitement de l'Information Medicale
17 Service de Radiologie et Imagerie Médicale [CHU Limoges]
18 Auteur indépendant
19 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
20 CHU Clermont-Ferrand
21 CHU Amiens-Picardie
22 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
23 CHU Caen
24 Hôpital des Charpennes [CHU - HCL]
25 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
26 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
27 CHU Montpellier
28 CHU - Hôpital Pasteur [Nice]
29 Hôpital Roger Salengro [Lille]
30 CHU Pitié-Salpêtrière [AP-HP]
31 AMU - Aix Marseille Université
32 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
33 UCBL - Université Claude Bernard Lyon 1
34 CHU Angers - Centre Hospitalier Universitaire d'Angers
35 Hôpital Raymond Poincaré [AP-HP]
36 CHU de Bordeaux Pellegrin [Bordeaux]
37 BMNST - Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques
38 UNISEP - Union pour la lutte contre la sclérose en plaques
39 CIC - Centre d'investigation clinique [Nancy]
40 HCL - Hospices Civils de Lyon
41 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
42 TIMONE - Hôpital de la Timone [CHU - APHM]
43 Fondation Eugène Devic EDMUS
44 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)
45 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
46 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
47 Hôpital Gui de Chauliac [CHU Montpellier]
48 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
49 CHU Gabriel Montpied [Clermont-Ferrand]
50 CHU Nîmes - Hôpital Universitaire Carémeau [Nîmes]
51 Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy]
52 Hôpital Charles Nicolle [Rouen]
53 Hôpital Pierre Zobda-Quitman [CHU de la Martinique]
54 Hôpital Dupuytren [CHU Limoges]
55 Hôpital Henri Mondor
56 CHU Reims - Hôpital universitaire Robert Debré [Reims]
57 Hôpital Bretonneau
58 Centre Hospitalier Sud Francilien
59 Hôpital Delafontaine
60 Centre Hospitalier René Dubos [Pontoise]
61 Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
62 CHV - Centre Hospitalier de Versailles André Mignot
Stephane Kremer
Elise Bannier
  • Function : Contributor
  • PersonId : 903894
Gildas Bonhomme
  • Function : Contributor
Béatrice Claise
  • Function : Contributor
Olivier Commowick
Jean-Marc Constans
Pascal Dardel
  • Function : Contributor
E. Gerardin
  • Function : Contributor
Sylvie Grand
T. Grenier
Lydiane Mondot
Nadya Pyatigorskaya
Jean-Philippe Ranjeva
Julien Savatovsky
  • Function : Contributor
Bruno Brochet
F. Guillemin
Christine Lebrun-Frenay
Lucilla Mansuy
  • Function : Contributor
Jean Pelletier
Bruno Stankoff
Marc Debouverie
  • Function : Contributor
  • PersonId : 762777
  • IdRef : 068986629
Gilles Edan
  • Function : Contributor
  • PersonId : 1014818
Jonathan Ciron
Patrick Vermersch
Pierre Labauge
Gilles Defer
  • Function : Contributor
Eric Thouvenot
Abdullatif Al-Khedr
  • Function : Contributor
Alain Créange
  • Function : Contributor
A. Maurousset
  • Function : Contributor
Thomas de Broucker
  • Function : Contributor

Abstract

PurposeNew multiple sclerosis (MS) disease-modifying therapies (DMTs), which exert beneficial effects through prevention of relapse, limitation of disability progression, and improvement of patients’ quality of life, have recently emerged. Nonetheless, these DMTs are not without associated complications (severe adverse events like. progressive multifocal leukoencephalopathy). Patient follow-up requires regular clinical evaluations and close monitoring with magnetic resonance imaging (MRI). Detection of new T2 lesions and potential brain atrophy measurements contribute to the evaluation of treatment effectiveness. Current MRI protocols for MS recommend the acquisition of an annual gadolinium (Gd) enhanced MRI, resulting in administration of high volume of contrast agents over time and Gd accumulation in the brain.MethodsA consensus report was established by neuroradiologists and neurologists from the French Observatory of MS, which aimed at reducing the number of Gd injections required during MS patient follow-up.RecommendationsThe French Observatory of MS recommends the use of macrocyclic Gd enhancement at time of diagnosis, when a new DMT is introduced, at 6-month re-baseline, and when previous scans are unavailable for comparison. Gd administration can be performed as an option in case of relapse or suspicion of intercurrent disease such as progressive multifocal leukoencephalopathy. Other follow-up MRIs do not require contrast enhancement, provided current and previous MRI acquisitions follow the same standardized protocol including 3D FLAIR sequences.
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hal-02570313 , version 1 (03-06-2022)

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Stephane Kremer, Salem Hannoun, Fabrice Bonneville, Francoise Durand-Dubief, Thomas Tourdias, et al.. New OFSEP recommendations for MRI assessment of multiple sclerosis patients: Special consideration for gadolinium deposition and frequent acquisitions. Journal de Neuroradiologie / Journal of Neuroradiology, 2020, 47 (4), pp.250-258. ⟨10.1016/j.neurad.2020.01.083⟩. ⟨hal-02570313⟩
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