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Article Dans Une Revue Data in Brief Année : 2016

Whole transcriptome data analysis of zebrafish mutants affecting muscle development

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Formation of the contractile myofibril of the skeletal muscle is a complex process which when perturbed leads to muscular dystrophy. Herein, we provide a mRNAseq dataset on three different zebrafish mutants affecting muscle organization during embryogenesis. These comprise the myosin folding chaperone unc45b (unc45b−/−), heat shock protein 90aa1.1 (hsp90aa1.1−/−) and the acetylcholine esterase (ache−/−) gene. The transcriptome analysis was performed in duplicate experiments at 72 h post-fertilization (hpf) for all three mutants, with two additional times of development (24 hpf and 48 hpf) for unc45b−/−. A total of 20 samples were analyzed by hierarchical clustering for differential gene expression. The data from this study support the observation made in Etard et al. (2015) [1] (http://dx.doi.org/10.1186/s13059-015-0825-8) that a failure to fold myosin activates a unique transcriptional program in the skeletal muscles that is different from that induced in stressed muscle cells.

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hal-02562031 , version 1 (04-05-2020)

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Olivier Armant, Victor Gourain, Christelle Etard, Uwe Strähle. Whole transcriptome data analysis of zebrafish mutants affecting muscle development. Data in Brief, 2016, 8, pp.61-68. ⟨10.1016/j.dib.2016.05.007⟩. ⟨hal-02562031⟩

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