A cell-intrinsic timer that operates during oligodendrocyte development - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BioEssays Année : 2000

A cell-intrinsic timer that operates during oligodendrocyte development

Résumé

Multicellular organisms develop on a predictable schedule that depends on both cell-intrinsic timers and sequential cell-cell interactions mediated by extracellular signals. The interplay between intracellular timers and extracellular signals is well illustrated by the development of oligodendrocytes, the cells that make the myelin in the vertebrate central nervous system. An intrinsic timing mechanism operates in each oligodendrocyte precursor cell to limit the length of time the cell divides before terminally differentiating. This mechanism consists of two components, a timing component, which depends on the mitogen platelet-derived growth factor (PDGF) and measures elapsed time, and an effector component, which depends on thyroid hormone and stops cell division and initiates differentiation at the appropriate time. The cell-cycle inhibitor p27/Kip1 accumulates in the precursor cells as they proliferate and is part of both components of the timer. It seems likely that similar timing mechanisms operate in other cell lineages.
Fichier principal
Vignette du fichier
Bioessays 2000 Durand.pdf (146.27 Ko) Télécharger le fichier
Origine : Accord explicite pour ce dépôt

Dates et versions

hal-02561082 , version 1 (24-11-2020)

Identifiants

Citer

Beatrice Claude Durand, Martin Raff. A cell-intrinsic timer that operates during oligodendrocyte development. BioEssays, 2000, 22 (1), pp.64-71. ⟨10.1002/(SICI)1521-1878⟩. ⟨hal-02561082⟩
38 Consultations
138 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More