Several industrial processes involving SiC coupling to Al-Ti alloys (e.g. metallization of SiC components, brazing of SiC parts) require an in-depth knowledge of Al-Ti/SiC interactions occurring at high temperatures. To this end, the surface reactivity between SiC and Al-Ti alloys (Al3Ti and (Al+Al3Ti) systems) was analyzed by specific experiments (wetting, DSC, microstructural examinations) as well as by a thermodynamic approach (CALPHAD method). An Al-C-Si-Ti thermodynamic database was successfully established to calculate several sections and projections in order to compare the computed, expected solid phases formed at the interface with those characterized in wetting experiments. In this way, the change in liquid and solid phases was interpreted and discussed, defining the Ti3(Al,Si)C2 mixed MAX-phase as the main interfacial product created by the chemical reaction, as a function of temperature and alloy composition. This work constitutes a guide for the choice of operating parameters in processes such as brazing or SiC metallization in microelectronic applications, in which the control of interfacial products is one of the most delicate production steps. The approach proposed to monitor the pathway of liquid composition with time and temperature during liquid/solid interaction, successfully applied to interpret the microstructure obtained in wetting experiments, is a promising method for interpreting more complex cases such as homogeneous or even heterogeneous brazing processes.