The early stages of the immune response of the European abalone Haliotis tuberculata to a Vibrio harveyi infection. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Developmental and Comparative Immunology Année : 2015

The early stages of the immune response of the European abalone Haliotis tuberculata to a Vibrio harveyi infection.

Résumé

Vibrio harveyi is a marine bacterial pathogen responsible for episodic abalone mortalities in France, Japan and Australia. In the European abalone, V. harveyi invades the circulatory system in a few hours after exposure and is lethal after 2 days of infection. In this study, we investigated the responses of European abalone immune cells over the first 24 h of infection. Results revealed an initial induction of immune gene expression including Rel/NF-kB, Mpeg and Clathrin. It is rapidly followed by a significant immunosuppression characterized by reduced cellular hemocyte parameters, immune response gene expressions and enzymatic activities. Interestingly, Ferritin was overexpressed after 24 h of infection suggesting that abalone attempt to counter V. harveyi infection using soluble effectors. Immune function alteration was positively correlated with V. harveyi concentration. This study provides the evidence that V. harveyi has a hemolytic activity and an immuno-suppressive effect in the European abalone.
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Dates et versions

hal-02555623 , version 1 (27-04-2020)

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Marion Cardinaud, Nolwenn M. Dheilly, Sylvain Huchette, Dario Moraga, Christine Paillard. The early stages of the immune response of the European abalone Haliotis tuberculata to a Vibrio harveyi infection.. Developmental and Comparative Immunology, 2015, 51 (2), pp.287-297. ⟨10.1016/j.dci.2015.02.019⟩. ⟨hal-02555623⟩
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