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Article Dans Une Revue Chest Année : 2020

One-year outcome of critically ill patients with systemic rheumatic disease: a multicenter cohort study

Résumé

Background: Critically ill patients with systemic rheumatic disease (SRD) have benefited from better provision of rheumatic and critical care in recent years. Recent comprehensive data regarding in-hospital mortality rates and, most importantly, long-term outcomes are scarce. Research question: The aim of this study was to assess short and long-term outcome of patients with SRD who were admitted to the ICU. Study design and methods: All records of patients with SRD who were admitted to ICU between 2006 and 2016 were reviewed. In-hospital and one-year mortality rates were assessed, and predictive factors of death were identified. Results: A total of 525 patients with SRD were included. Causes of admission were most frequently shock (40.8%) and acute respiratory failure (31.8%). Main diagnoses were infection (39%) and SRD flare-up (35%). In-hospital and one-year mortality rates were 30.5% and 37.7%, respectively. Predictive factors that were associated with in-hospital and one-year mortalities were, respectively, age, prior corticosteroid therapy, simplified acute physiology score II ≥50, need for invasive mechanical ventilation, or need for renal replacement therapy. Knaus scale C or D and prior conventional disease modifying antirheumatic drug therapy was associated independently with death one-year after ICU admission. Interpretation: Critically ill patients with SRD had a fair outcome after an ICU stay. Increased age, prior corticosteroid therapy, and severity of critical illness were associated significantly with short- and long-term mortality rates. The one-year mortality rate was also associated with prior health status and conventional disease modifying antirheumatic drug therapy.
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Dates et versions

hal-02543275 , version 1 (03-11-2020)

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R. Larcher, Marc Pineton de Chambrun, Fanny Garnier, Emma Rubenstein, Julie Carr, et al.. One-year outcome of critically ill patients with systemic rheumatic disease: a multicenter cohort study. Chest, 2020, ⟨10.1016/j.chest.2020.03.050⟩. ⟨hal-02543275⟩
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