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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2003

Executive and social behaviors under nicotinic receptor regulation

Executive and social behaviors under nicotinic receptor regulation.

Sylvie Granon
Philippe Faure
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Jean-Pierre Changeux
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Résumé

Nicotine enhances several cognitive and psychomotor behaviors, and nicotinic antagonists cause impairments in tasks requiring cognitive effort. To explore the contribution of nicotinic receptors to complex cognitive functions, we developed an automated method to investigate sequential locomotor behavior in the mouse and an analysis of social behavior. We show that, in the beta2-/- mutant, the high-order spatiotemporal organization of locomotor behavior, together with conflict resolution and social interaction, is selectively dissociated from low-level, more automatic motor behaviors. Such deficits in executive functions resemble the rigid and asocial behavior found in some psychopathological disorders such as autism and attention deficit hyperactivity disorder.

Dates et versions

hal-02541881 , version 1 (14-04-2020)

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Sylvie Granon, Philippe Faure, Jean-Pierre Changeux. Executive and social behaviors under nicotinic receptor regulation. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100 (16), pp.9596-9601. ⟨10.1073/pnas.1533498100⟩. ⟨hal-02541881⟩
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