The high manganese austenitic steels with low stacking fault energy (SFE) present outstanding mechanical properties due to the occurrence of two strain mechanisms: dislocation glide and twinning. Both mechanisms are anisotropic. In this paper, we analyzed the effect of monotonous loading path on the texture, the deformation twinning and the stress–strain response of polycrystalline high Mn TWIP steel. Experimental data were compared to predicted results obtained by two polycrystalline models. These two models are based on the same single crystal constitutive equations but differ from the homogenization scheme. The good agreement between experiments and calculations suggest that the texture plays a key role in twinning activity and kinetics with regard to the intergranular stress heterogeneities. Rolling direction simple shear induces single twinning while rolling and transverse direction uniaxial tensions induce multi-twinning leading to lower twin volume fractions due to twin–twin interactions.