The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies
Eleanor Watts
(1)
,
Aurora Perez‐cornago
(1)
,
Paul Appleby
(1)
,
Demetrius Albanes
(2)
,
Eva Ardanaz
(3)
,
Amanda Black
(2)
,
H. Bas Bueno‐de‐mesquita
(4)
,
June Chan
(5)
,
Chu Chen
(6)
,
S.A. Paul Chubb
(7)
,
Michael Cook
(2)
,
Mélanie Deschasaux
(8)
,
Jenny Donovan
(9)
,
Dallas R English
(10)
,
Leon Flicker
(7)
,
Neal Freedman
(2)
,
Pilar Galan
(8)
,
Graham G Giles
(10)
,
Edward Giovannucci
(11, 12)
,
Marc Gunter
(13)
,
Laurel Habel
(14)
,
Christel Häggström
(15)
,
Christopher Haiman
(16)
,
Freddie C. Hamdy
(17)
,
Serge Hercberg
(8)
,
Jeff Holly
(9)
,
Jiaqi Huang
(2)
,
Wen‐yi Huang
(2)
,
Mattias Johansson
(13)
,
Rudolf Kaaks
(18)
,
Tatsuhiko Kubo
(19)
,
J. Athene Lane
(9)
,
Tracy Layne
(20)
,
Loïc Le Marchand
(21)
,
Richard Martin
(9)
,
E. Jeffrey Metter
(22)
,
Kazuya Mikami
(23)
,
Roger L Milne
(10)
,
Howard Morris
(24)
,
Lorelei Mucci
(11)
,
David Neal
(17)
,
Marian Neuhouser
(6)
,
Steven Oliver
(25)
,
Kim Overvad
(26)
,
Kotaro Ozasa
(27)
,
Valeria Pala
(28)
,
Claire Pernar
(11)
,
Michael Pollak
(29)
,
Mari‐anne Rowlands
(9)
,
Catherine Schaefer
(14)
,
Jeannette Schenk
(6)
,
Pär Stattin
(30)
,
Akiko Tamakoshi
(31)
,
Elin Thysell
(15)
,
Mathilde Touvier
(8)
,
Antonia Trichopoulou
(32)
,
Konstantinos Tsilidis
(33, 34)
,
Stephen K. van den Eeden
(14)
,
Stephanie Weinstein
(2)
,
Lynne Wilkens
(21)
,
Bu Yeap
(7)
,
Timothy Key
(35)
,
Naomi E. Allen
(1)
,
Ruth Travis
(35)
1
Nuffield Department of Population Health [Oxford]
2 NCI-NIH - National Cancer Institute [Bethesda]
3 Public Health Institute of Navarra
4 RIVM - National Institute for Public Health and the Environment [Bilthoven]
5 UC San Francisco - University of California [San Francisco]
6 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
7 UWA - The University of Western Australia
8 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
9 University of Bristol [Bristol]
10 Melbourne School of Population and Global Health [Melbourne]
11 Harvard T.H. Chan School of Public Health
12 HMS - Harvard Medical School [Boston]
13 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
14 Kaiser Permanente
15 Umeå University, Sweden
16 Keck School of Medicine [Los Angeles]
17 Nuffield - Nuffield
18 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
19 UEOH - University of Occupational and Environmental Health [Kitakyushu]
20 MSSM - Icahn School of Medicine at Mount Sinai [New York]
21 UH - University of Hawai'i [Honolulu]
22 UTHSC - The University of Tennessee Health Science Center [Memphis]
23 Japanese Red Cross Kyoto Daiichi Hospital
24 SA Pathology [Adelaide, SA, Australia]
25 University of York [York, UK]
26 Aarhus University [Aarhus]
27 RERF - Radiation Effects Research Foundation [Hiroshima City, Japan]
28 Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan]
29 McGill University = Université McGill [Montréal, Canada]
30 Uppsala Universitet [Uppsala]
31 Hokkaido University [Sapporo, Japan]
32 Hellenic Health Foundation
33 Imperial College London
34 University of Ioannina
35 University of Oxford
2 NCI-NIH - National Cancer Institute [Bethesda]
3 Public Health Institute of Navarra
4 RIVM - National Institute for Public Health and the Environment [Bilthoven]
5 UC San Francisco - University of California [San Francisco]
6 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
7 UWA - The University of Western Australia
8 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
9 University of Bristol [Bristol]
10 Melbourne School of Population and Global Health [Melbourne]
11 Harvard T.H. Chan School of Public Health
12 HMS - Harvard Medical School [Boston]
13 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
14 Kaiser Permanente
15 Umeå University, Sweden
16 Keck School of Medicine [Los Angeles]
17 Nuffield - Nuffield
18 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
19 UEOH - University of Occupational and Environmental Health [Kitakyushu]
20 MSSM - Icahn School of Medicine at Mount Sinai [New York]
21 UH - University of Hawai'i [Honolulu]
22 UTHSC - The University of Tennessee Health Science Center [Memphis]
23 Japanese Red Cross Kyoto Daiichi Hospital
24 SA Pathology [Adelaide, SA, Australia]
25 University of York [York, UK]
26 Aarhus University [Aarhus]
27 RERF - Radiation Effects Research Foundation [Hiroshima City, Japan]
28 Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan]
29 McGill University = Université McGill [Montréal, Canada]
30 Uppsala Universitet [Uppsala]
31 Hokkaido University [Sapporo, Japan]
32 Hellenic Health Foundation
33 Imperial College London
34 University of Ioannina
35 University of Oxford
Mélanie Deschasaux
- Fonction : Auteur
- PersonId : 183648
- IdHAL : melanie-deschasaux
- ORCID : 0000-0002-3359-420X
- IdRef : 236007823
Pilar Galan
- Fonction : Auteur
- PersonId : 756893
- ORCID : 0000-0003-1706-3107
Serge Hercberg
- Fonction : Auteur
- PersonId : 1136672
- ORCID : 0000-0002-3168-1350
- IdRef : 02858709X
Mattias Johansson
- Fonction : Auteur
- PersonId : 767866
- ORCID : 0000-0002-3116-5081
- IdRef : 195811100
Valeria Pala
- Fonction : Auteur
- PersonId : 764917
- ORCID : 0000-0001-5438-970X
Mathilde Touvier
- Fonction : Auteur
- PersonId : 1136541
Résumé
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.
|
Titre |
en
The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies
|
Auteur(s) |
Eleanor Watts
1
, Aurora Perez‐cornago
1
, Paul Appleby
1
, Demetrius Albanes
2
, Eva Ardanaz
3
, Amanda Black
2
, H. Bas Bueno‐de‐mesquita
4
, June Chan
5
, Chu Chen
6
, S.A. Paul Chubb
7
, Michael Cook
2
, Mélanie Deschasaux
8
, Jenny Donovan
9
, Dallas R English
10
, Leon Flicker
7
, Neal Freedman
2
, Pilar Galan
8
, Graham G Giles
10
, Edward Giovannucci
11, 12
, Marc Gunter
13
, Laurel Habel
14
, Christel Häggström
15
, Christopher Haiman
16
, Freddie C. Hamdy
17
, Serge Hercberg
8
, Jeff Holly
9
, Jiaqi Huang
2
, Wen‐yi Huang
2
, Mattias Johansson
13
, Rudolf Kaaks
18
, Tatsuhiko Kubo
19
, J. Athene Lane
9
, Tracy Layne
20
, Loïc Le Marchand
21
, Richard Martin
9
, E. Jeffrey Metter
22
, Kazuya Mikami
23
, Roger L Milne
10
, Howard Morris
24
, Lorelei Mucci
11
, David Neal
17
, Marian Neuhouser
6
, Steven Oliver
25
, Kim Overvad
26
, Kotaro Ozasa
27
, Valeria Pala
28
, Claire Pernar
11
, Michael Pollak
29
, Mari‐anne Rowlands
9
, Catherine Schaefer
14
, Jeannette Schenk
6
, Pär Stattin
30
, Akiko Tamakoshi
31
, Elin Thysell
15
, Mathilde Touvier
8
, Antonia Trichopoulou
32
, Konstantinos Tsilidis
33, 34
, Stephen K. van den Eeden
14
, Stephanie Weinstein
2
, Lynne Wilkens
21
, Bu Yeap
7
, Timothy Key
35
, Naomi E. Allen
1
, Ruth Travis
35
1
Nuffield Department of Population Health [Oxford]
( 479964 )
- Oxford OX1 3PA
- Royaume-Uni
2
NCI-NIH -
National Cancer Institute [Bethesda]
( 305678 )
- BG 9609 MSC 9760, 9609 Medical Center Drive, Bethesda, MD 20892-9760
- États-Unis
3
Public Health Institute of Navarra
( 567789 )
- Pamplona
- Espagne
4
RIVM -
National Institute for Public Health and the Environment [Bilthoven]
( 453112 )
- Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven / PO Box 1, 3720 BA Bilthoven
- Pays-Bas
5
UC San Francisco -
University of California [San Francisco]
( 190541 )
- 505 Parnassus Ave, San Francisco, CA 94143
- États-Unis
6
FHCRC -
Fred Hutchinson Cancer Research Center [Seattle]
( 41823 )
- 1100 Fairview Ave. N. PO Box 19024 Seattle, WA 98109
- États-Unis
7
UWA -
The University of Western Australia
( 4177 )
- 35 Stirling Highway
Perth WA 6009 Australia
- Australie
8
CRESS - U1153 -
Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
( 516244 )
- Université Paris 13, U.F.R de Santé, Médecine et Biologie Humaine
Rez-de-chaussée, porte 26
74 rue Marcel Cachin
93017 Bobigny cedex
- France
9
University of Bristol [Bristol]
( 220393 )
- Senate House, Tyndall Avenue, Bristol BS8 1TH
- Royaume-Uni
10
Melbourne School of Population and Global Health [Melbourne]
( 549086 )
- 207 Bouverie St, Carlton VIC 3053, Australie
- Australie
11
Harvard T.H. Chan School of Public Health
( 458379 )
- 677 Huntington Avenue, Boston, MA 02115
- États-Unis
12
HMS -
Harvard Medical School [Boston]
( 130467 )
- 25 Shattuck Street Boston, MA 02115
- États-Unis
13
UNICANCER/CRCL -
Centre de Recherche en Cancérologie de Lyon
( 139829 )
- 28, rue Laennec - 69373 Lyon
- France
14
Kaiser Permanente
( 308749 )
- Oakland, Californie, États-Unis
- États-Unis
15
Umeå University, Sweden
( 548056 )
- Umeå University
901 87 Umeå, Sweden
- Suède
16
Keck School of Medicine [Los Angeles]
( 308698 )
- 1975 Zonal Ave., Los Angeles, CA 90033
- États-Unis
17
Nuffield -
Nuffield
( 172365 )
- Nuffield College New Road Oxford OX1 1NF
- France
18
DKFZ -
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
( 150185 )
- German Cancer Research Center Im Neuenheimer Feld 280 D-69120 Heidelberg
- Allemagne
19
UEOH -
University of Occupational and Environmental Health [Kitakyushu]
( 325231 )
- 807-8556 Fukuoka Prefecture, Kitakyushu, Yahatanishi Ward, Iseigaoka
- Japon
20
MSSM -
Icahn School of Medicine at Mount Sinai [New York]
( 354552 )
- 1 Gustave L. Levy Place
New York, NY 10029-5674
- États-Unis
21
UH -
University of Hawai'i [Honolulu]
( 482712 )
- 2500 Campus Rd, Honolulu, HI 96822
- États-Unis
22
UTHSC -
The University of Tennessee Health Science Center [Memphis]
( 563416 )
- Memphis, Tennessee, TN 38163
- États-Unis
23
Japanese Red Cross Kyoto Daiichi Hospital
( 1005779 )
- Kyoto
- Japon
24
SA Pathology [Adelaide, SA, Australia]
( 575321 )
- Australie
25
University of York [York, UK]
( 124942 )
- Heslington, York, YO10 5DD
- Royaume-Uni
26
Aarhus University [Aarhus]
( 19908 )
- Nordre Ringgade 1 DK-8000 Aarhus C
- Danemark
27
RERF -
Radiation Effects Research Foundation [Hiroshima City, Japan]
( 1060322 )
- Hiroshima
- Japon
28
Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan]
( 339445 )
- Via Giacomo Venezian, 1, 20133 Milano MI, Italie
- Italie
29
McGill University = Université McGill [Montréal, Canada]
( 134741 )
- 845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4
- Canada
30
Uppsala Universitet [Uppsala]
( 219663 )
- P.O. Box 256, SE-751 05 Uppsala
- Suède
31
Hokkaido University [Sapporo, Japan]
( 304963 )
- 5 Chome Kita 8 Jōnishi, Kita Ward, Sapporo, Hokkaido Prefecture 060-0808, Japon
- Japon
32
Hellenic Health Foundation
( 165333 )
- Kaisareias 13 & Alexandroupoleos
GR-115 27, Athens, Greece
- Grèce
33
Imperial College London
( 69530 )
- South Kensington Campus, London SW7 2AZ
- Royaume-Uni
34
University of Ioannina
( 329376 )
- 45110 Ioannina
- Grèce
35
University of Oxford
( 302612 )
- Wellington Square, Oxford OX1 2JD
- Royaume-Uni
|
Audience |
Internationale
|
Version du document |
version éditeur
|
Page/Identifiant |
3244-3256
|
Numéro |
12
|
Volume |
145
|
Langue du document |
Anglais
|
Public visé |
Scientifique
|
Nom de la revue |
|
Vulgarisation |
Non
|
Sous-type de document pour les Articles |
Research article
|
Comité de lecture |
Oui
|
Date de publication |
2019-06-26
|
Licence |
Paternité
|
Domaine(s) |
|
DOI | 10.1002/ijc.32276 |
Pubmed Id | 30873591 |
UT key WOS | 000491231500007 |
Origine :
Fichiers éditeurs autorisés sur une archive ouverte
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