A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
Ruth Travis
(1)
,
Paul Appleby
(1)
,
Richard Martin
(2)
,
Jeff M.P. Holly
(3)
,
Demetrius Albanes
(4)
,
Amanda Black
(4)
,
H. Bas Bueno-De-Mesquita
(5)
,
June Chan
(6)
,
Chu Chen
(7)
,
María-Dolores Chirlaque
(8, 9)
,
Michael Cook
(4)
,
Mélanie Deschasaux
(10)
,
Jenny Donovan
(2)
,
Luigi Ferrucci
(11)
,
Pilar Galan
(10)
,
Graham G Giles
(12)
,
Edward Giovannucci
(13)
,
Marc Gunter
(14)
,
Laurel Habel
(15)
,
Freddie C. Hamdy
(16)
,
Kathy Helzlsouer
(17)
,
Serge Hercberg
(10)
,
Robert Hoover
(4)
,
Joseph A.M.J.L. Janssen
(18)
,
Rudolf Kaaks
(19)
,
Tatsuhiko Kubo
(20)
,
Loïc Le Marchand
(21)
,
E. Jeffrey Metter
(11)
,
Kazuya Mikami
(22)
,
Joan Morris
(23)
,
David Neal
(24)
,
Marian Neuhouser
(7)
,
Kotaro Ozasa
(25)
,
Domenico Palli
(26)
,
Elizabeth Platz
(27)
,
Michael Pollak
(28)
,
Alison Price
(1)
,
Monique J Roobol
(18)
,
Catherine Schaefer
(15)
,
Jeannette Schenk
(7, 29)
,
Gianluca Severi
(30, 31)
,
Meir J Stampfer
(13)
,
Pär Stattin
(32)
,
Akiko Tamakoshi
(33)
,
Catherine M Tangen
(7)
,
Mathilde Touvier
(10)
,
Nicholas Wald
(24)
,
Noel Weiss
(31)
,
Regina Ziegler
(4)
,
Timothy Key
(1)
,
Naomi E. Allen
(1)
1
Nuffield Department of Population Health [Oxford]
2 School of Social and Community Medicine [Bristol]
3 University of Bristol [Bristol]
4 NCI-NIH - National Cancer Institute [Bethesda]
5 RIVM - National Institute for Public Health and the Environment [Bilthoven]
6 UC San Francisco - University of California [San Francisco]
7 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
8 CIBERESP - Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública
9 Department of Epidemiology, Murcia Regional Health Council
10 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
11 NIA - National Institute on Aging [Bethesda, USA]
12 University of Melbourne
13 Harvard School of Public Health
14 Imperial College London
15 Kaiser Permanente
16 Nuffield - Nuffield
17 Mercy Medical Center
18 Erasmus MC - Erasmus University Medical Center [Rotterdam]
19 Division of Cancer Epidemiology
20 UEOH - University of Occupational and Environmental Health [Kitakyushu]
21 UHM - University of Hawai‘i [Mānoa]
22 Kyoto Prefectural University of Medicine [Kyoto, Japon]
23 QMUL - Queen Mary University of London
24 CAM - University of Cambridge [UK]
25 RERF - Radiation Effects Research Foundation [Hiroshima City, Japan]
26 Molecular and Nutritional Epidemiology Unit
27 Johns Hopkins Bloomberg School of Public Health [Baltimore]
28 Cancer Prevention Research Unit, Department of Oncology
29 University of Washington [Seattle]
30 Cancer Epidemiology Centre
31 Human Genetics Foundation (HuGeF)
32 Department of Surgical and Perioperative Sciences, Urology and Andrology
33 Hokkaido University Hospital [Sapporo]
2 School of Social and Community Medicine [Bristol]
3 University of Bristol [Bristol]
4 NCI-NIH - National Cancer Institute [Bethesda]
5 RIVM - National Institute for Public Health and the Environment [Bilthoven]
6 UC San Francisco - University of California [San Francisco]
7 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]
8 CIBERESP - Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública
9 Department of Epidemiology, Murcia Regional Health Council
10 CRESS - U1153 - Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
11 NIA - National Institute on Aging [Bethesda, USA]
12 University of Melbourne
13 Harvard School of Public Health
14 Imperial College London
15 Kaiser Permanente
16 Nuffield - Nuffield
17 Mercy Medical Center
18 Erasmus MC - Erasmus University Medical Center [Rotterdam]
19 Division of Cancer Epidemiology
20 UEOH - University of Occupational and Environmental Health [Kitakyushu]
21 UHM - University of Hawai‘i [Mānoa]
22 Kyoto Prefectural University of Medicine [Kyoto, Japon]
23 QMUL - Queen Mary University of London
24 CAM - University of Cambridge [UK]
25 RERF - Radiation Effects Research Foundation [Hiroshima City, Japan]
26 Molecular and Nutritional Epidemiology Unit
27 Johns Hopkins Bloomberg School of Public Health [Baltimore]
28 Cancer Prevention Research Unit, Department of Oncology
29 University of Washington [Seattle]
30 Cancer Epidemiology Centre
31 Human Genetics Foundation (HuGeF)
32 Department of Surgical and Perioperative Sciences, Urology and Andrology
33 Hokkaido University Hospital [Sapporo]
Mélanie Deschasaux
- Fonction : Auteur
- PersonId : 183648
- IdHAL : melanie-deschasaux
- ORCID : 0000-0002-3359-420X
- IdRef : 236007823
Pilar Galan
- Fonction : Auteur
- PersonId : 756893
- ORCID : 0000-0003-1706-3107
Serge Hercberg
- Fonction : Auteur
- PersonId : 1136672
- ORCID : 0000-0002-3168-1350
- IdRef : 02858709X
Gianluca Severi
- Fonction : Auteur
- PersonId : 775780
- IdHAL : gianluca-severi
- ORCID : 0000-0001-7157-419X
- IdRef : 198040598
Mathilde Touvier
- Fonction : Auteur
- PersonId : 1136541
Résumé
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
|
Résumé |
en
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.
|
Auteur(s) |
Ruth Travis
1
, Paul Appleby
1
, Richard Martin
2
, Jeff M.P. Holly
3
, Demetrius Albanes
4
, Amanda Black
4
, H. Bas Bueno-De-Mesquita
5
, June Chan
6
, Chu Chen
7
, María-Dolores Chirlaque
8, 9
, Michael Cook
4
, Mélanie Deschasaux
10
, Jenny Donovan
2
, Luigi Ferrucci
11
, Pilar Galan
10
, Graham G Giles
12
, Edward Giovannucci
13
, Marc Gunter
14
, Laurel Habel
15
, Freddie C. Hamdy
16
, Kathy Helzlsouer
17
, Serge Hercberg
10
, Robert Hoover
4
, Joseph A.M.J.L. Janssen
18
, Rudolf Kaaks
19
, Tatsuhiko Kubo
20
, Loïc Le Marchand
21
, E. Jeffrey Metter
11
, Kazuya Mikami
22
, Joan Morris
23
, David Neal
24
, Marian Neuhouser
7
, Kotaro Ozasa
25
, Domenico Palli
26
, Elizabeth Platz
27
, Michael Pollak
28
, Alison Price
1
, Monique J Roobol
18
, Catherine Schaefer
15
, Jeannette Schenk
7, 29
, Gianluca Severi
30, 31
, Meir J Stampfer
13
, Pär Stattin
32
, Akiko Tamakoshi
33
, Catherine M Tangen
7
, Mathilde Touvier
10
, Nicholas Wald
24
, Noel Weiss
31
, Regina Ziegler
4
, Timothy Key
1
, Naomi E. Allen
1
1
Nuffield Department of Population Health [Oxford]
( 479964 )
- Oxford OX1 3PA
- Royaume-Uni
2
School of Social and Community Medicine [Bristol]
( 186485 )
- Tyndall Avenue,
Bristol, BS8 1TH
- Royaume-Uni
3
University of Bristol [Bristol]
( 220393 )
- Senate House, Tyndall Avenue, Bristol BS8 1TH
- Royaume-Uni
4
NCI-NIH -
National Cancer Institute [Bethesda]
( 305678 )
- BG 9609 MSC 9760, 9609 Medical Center Drive, Bethesda, MD 20892-9760
- États-Unis
5
RIVM -
National Institute for Public Health and the Environment [Bilthoven]
( 453112 )
- Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven / PO Box 1, 3720 BA Bilthoven
- Pays-Bas
6
UC San Francisco -
University of California [San Francisco]
( 190541 )
- 505 Parnassus Ave, San Francisco, CA 94143
- États-Unis
7
FHCRC -
Fred Hutchinson Cancer Research Center [Seattle]
( 41823 )
- 1100 Fairview Ave. N. PO Box 19024 Seattle, WA 98109
- États-Unis
8
CIBERESP -
Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública
( 193531 )
- C/Melchor Fernández Almagro 3-5, Madrid, 28029
- Espagne
9
Department of Epidemiology, Murcia Regional Health Council
( 567788 )
- Murcia
- Espagne
10
CRESS - U1153 -
Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle
( 516244 )
- Université Paris 13, U.F.R de Santé, Médecine et Biologie Humaine
Rez-de-chaussée, porte 26
74 rue Marcel Cachin
93017 Bobigny cedex
- France
11
NIA -
National Institute on Aging [Bethesda, USA]
( 193257 )
- Bethesda, Maryland
- États-Unis
12
University of Melbourne
( 306322 )
- Parkville VIC 3010
- Australie
13
Harvard School of Public Health
( 408186 )
- 665 Huntington Ave, Boston, MA 02115
- États-Unis
14
Imperial College London
( 69530 )
- South Kensington Campus, London SW7 2AZ
- Royaume-Uni
15
Kaiser Permanente
( 308749 )
- Oakland, Californie, États-Unis
- États-Unis
16
Nuffield -
Nuffield
( 172365 )
- Nuffield College New Road Oxford OX1 1NF
- France
17
Mercy Medical Center
( 517416 )
- États-Unis
18
Erasmus MC -
Erasmus University Medical Center [Rotterdam]
( 308157 )
- Rotterdam
- Pays-Bas
19
Division of Cancer Epidemiology
( 88701 )
- Heidelberg
- Allemagne
20
UEOH -
University of Occupational and Environmental Health [Kitakyushu]
( 325231 )
- 807-8556 Fukuoka Prefecture, Kitakyushu, Yahatanishi Ward, Iseigaoka
- Japon
21
UHM -
University of Hawai‘i [Mānoa]
( 529665 )
- 1890 East-West Rd, Honolulu, HI 96822
- États-Unis
22
Kyoto Prefectural University of Medicine [Kyoto, Japon]
( 335405 )
- Japon
23
QMUL -
Queen Mary University of London
( 303063 )
- Mile End Road, London E1 4NS
- Royaume-Uni
24
CAM -
University of Cambridge [UK]
( 237843 )
- The Old Schools, Trinity Lane, Cambridge CB2 1TN
- Royaume-Uni
25
RERF -
Radiation Effects Research Foundation [Hiroshima City, Japan]
( 1060322 )
- Hiroshima
- Japon
26
Molecular and Nutritional Epidemiology Unit
( 113485 )
- 50139;Florence
- Italie
27
Johns Hopkins Bloomberg School of Public Health [Baltimore]
( 466567 )
- 615 N Wolfe St, Baltimore, MD 21205
- États-Unis
28
Cancer Prevention Research Unit, Department of Oncology
( 225602 )
- Montreal (QC)
- Canada
29
University of Washington [Seattle]
( 300433 )
- Seattle, Washington 98105
- États-Unis
30
Cancer Epidemiology Centre
( 556465 )
- Melbourne
- Australie
31
Human Genetics Foundation (HuGeF)
( 495617 )
- V. Nizza 52, I-10126, Torino
- Italie
32
Department of Surgical and Perioperative Sciences, Urology and Andrology
( 113733 )
- 901 85;Umeå
- Suède
33
Hokkaido University Hospital [Sapporo]
( 474173 )
- Japon
|
Langue du document |
Anglais
|
Nom de la revue |
|
Volume |
76
|
Numéro |
8
|
Page/Identifiant |
2288-2300
|
Date de publication |
2016-04-14
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Public visé |
Scientifique
|
Sous-type de document pour les Articles |
Research article
|
Domaine(s) |
|
Mots-clés |
en
growth-factor-i, factor-binding protein-2, serum-insulin, factor axis, igfbp-3, hyperplasia
fr
factor (igf)-i, susceptibility loci, prevention trial, diet
|
DOI | 10.1158/0008-5472.CAN-15-1551 |
ProdINRA | 354843 |
Pubmed Id | 26921328 |
PubMed Central | PMC4873385 |
UT key WOS | 000374170700025 |
Origine :
Fichiers produits par l'(les) auteur(s)
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