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Article Dans Une Revue Chemistry - A European Journal Année : 2020

Iodinated Metallacrowns: Toward Combined Bimodal Near‐Infrared and X‐Ray Contrast Imaging Agents

Résumé

Multimodal probes capable of combining imaging modalities within a single molecule are in high demand today as they can provide information at both molecular and anatomical levels. Herein, a study was conducted on a series of gallium(III)/lanthanide(III) bis(12-MC-4) metallacrowns (MCs) with the general composition {Ln[12-MCGa III N(shi) -4]}2 (iph)4 (Ln-Ix , x=0, 4, 8, 12), where shi and iph are salicylhydroximate and isophthalate ligands, respectively, or their iodinated derivatives. For Yb-Ix , the attenuation in X-ray computed tomography (XCT) imaging and near-infrared (NIR) luminescence properties can be finely tuned by controlled structural modifications based on iodo groups. Solutions of Yb-Ix appear to be 22-40 times more efficient as XCT agents in comparison to the commercially available iobitridol, while providing an intense emission signal in the NIR range with total quantum yields up to 8.6 %, which are among the highest values reported so far. Therefore, these molecules are promising potential bimodal agents for combined NIR luminescence and XCT imaging.
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Dates et versions

hal-02525042 , version 1 (24-11-2020)

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Jacob Lutter, Svetlana Eliseeva, Guillaume Collet, Ivana Martinić, Jeff Kampf, et al.. Iodinated Metallacrowns: Toward Combined Bimodal Near‐Infrared and X‐Ray Contrast Imaging Agents. Chemistry - A European Journal, 2020, 26 (6), pp.1274-1277. ⟨10.1002/chem.201905241⟩. ⟨hal-02525042⟩
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