Méthodes d'exploration des fonctions plaquettaires : marqueurs biologiques de l'activation des plaquettes humaines in vivo et in vitro. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Annales de Biologie Clinique Année : 1986

Méthodes d'exploration des fonctions plaquettaires : marqueurs biologiques de l'activation des plaquettes humaines in vivo et in vitro.

Résumé

Platelets play a key role in hemostasis, thrombosis, atherosclerosis and their pathological consequences. It is possible to follow platelet activation in vivo by measuring bleeding time, platelet count, existence of circulating platelet aggregates or platelet survival and sequestration. In vitro tests include measurement of platelet adhesion, aggregation alpha, and dense granule secretion. It is also possible to follow biochemical events linked to platelet activation such as prostaglandin metabolism, Ca2+ levels or platelet membrane modifications (receptors, glycoproteins, coagulant activities, antigens). Some of these markers of platelet activation are modified in diseases (thrombotic events, hyperlipoproteinemia) and the use of artificial surfaces. It is not always possible to know if the modifications are the cause or the consequence of the pathological event. Unfortunately, some results are questionable because of methodological procedures. Some of these tests have been used to follow the involvement of platelets in a pathological event or to evaluate a prethrombotic state in a patient. It is not yet possible to identify directly, or by the mean of a marker of platelet activation, a patient who is likely to experience a thrombotic episode.
Fichier non déposé

Dates et versions

hal-02516535 , version 1 (23-03-2020)

Identifiants

  • HAL Id : hal-02516535 , version 1

Citer

S Hemmendinger, Alain Beretz, Francois Lanza, Jean-Pierre Cazenave. Méthodes d'exploration des fonctions plaquettaires : marqueurs biologiques de l'activation des plaquettes humaines in vivo et in vitro.. Annales de Biologie Clinique, 1986, 44 (4), pp.347-352. ⟨hal-02516535⟩

Collections

SITE-ALSACE
28 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More