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Article Dans Une Revue Microvascular Research Année : 2020

Murine double minute-2 mediates exercise-induced angiogenesis in adipose tissue of diet-induced obese mice

Résumé

This study aimed to determine the effects of physical exercise on the angio-adaptive response in adipose tissue following weight loss in a mouse model of diet-induced obesity. We hypothesized that physical exercise stimulates angiogenesis through the regulation of Vascular endothelial growth factor-A (VEGF-A) pro-/Thrombospondin-1 (TSP-1) anti-angiogenic signal under the control of the Murine double-minute 2/Forkhead box Os (Mdm2/FoxOs) axis, as reported in skeletal muscle.
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Dates et versions

hal-02515008 , version 1 (08-07-2020)

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Thomas Loustau, Eugénie Coudiere, Esma Karkeni, Jean-Francois Landrier, Bernard Jover, et al.. Murine double minute-2 mediates exercise-induced angiogenesis in adipose tissue of diet-induced obese mice. Microvascular Research, 2020, pp.104003. ⟨10.1016/j.mvr.2020.104003⟩. ⟨hal-02515008⟩
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