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Article Dans Une Revue PeerJ Année : 2017

Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine

Andrzej Hudecki
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Joanna Gola
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Saeid Ghavami
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Magdalena Skonieczna
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Jarosław Markowski
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Wirginia Likus
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Magdalena Lewandowska
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Wojciech Maziarz
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Résumé

With the rapid advancement of regenerative medicine technologies, there is an urgent need for the development of new, cell-friendly techniques for obtaining nanofibers-the raw material for an artificial extracellular matrix production. We investigated the structure and properties of PCL 10 nanofibers, PCL 5 /PCL 10 core-shell type nanofibers, as well as PCL 5 /PCL Ag nanofibres prepared by electrospinning. For the production of the fiber variants, a 5-10% solution of polycaprolactone (PCL) (M w = 70,000-90,000), dissolved in a mixture of formic acid and acetic acid at a ratio of 70:30 m/m was used. In order to obtain fibers containing PCL Ag 1% of silver nanoparticles was added. The electrospin was conducted using the above-described solutions at the electrostatic field. The subsequent bio-analysis shows that synthesis of core-shell nanofibers PCL 5 /PCL 10 , and the silver-doped variant nanofiber core shell PCL 5 /PCL Ag , by using organic acids as solvents, is a robust technique. Furthermore, the incorporation of silver nanoparticles into PCL 5 /PCL Ag makes such nanofibers toxic to model microbes without compromising its biocompatibility. Nanofibers obtained such way may then be used in regenerative medicine, for the preparation of extracellular scaffolds: (i) for controlled bone regeneration due to the long decay time of the PCL, (ii) as bioscaffolds for generation of other types of artificial tissues, (iii) and as carriers of nanocapsules for local drug delivery. Furthermore, the used solvents are significantly less toxic than the solvents for polycaprolactone currently commonly used in electrospin, like for How to cite this article Hudecki et al. (2017), Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospin-ning as tissue scaffolds in regenerative medicine. PeerJ 5:e4125; DOI 10.7717/peerj.4125
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hal-02506713 , version 1 (12-03-2020)

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Andrzej Hudecki, Joanna Gola, Saeid Ghavami, Magdalena Skonieczna, Jarosław Markowski, et al.. Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine. PeerJ, 2017, 5, pp.e4125. ⟨10.7717/peerj.4125⟩. ⟨hal-02506713⟩
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