Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2019

Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

Résumé

Stereoselective fluorination is investigated as a method for modulating the properties of a cyclic RGD-containing tetrapeptide. Three key outcomes of fluorination are assessed: (i) the effect on peptide cyclisation efficiency; (ii) the ability to fine-tune the molecular conformation; and (iii) the effect on the cyclic peptides' biological activity. Fluorination is found to exert pronounced effects against all three criteria.

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Dates et versions

hal-02503849 , version 1 (10-03-2020)

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Catherine Au, Christina Gonzalez, Yun Cheuk Leung, Flora Mansour, Johny Trinh, et al.. Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination. Organic & Biomolecular Chemistry, 2019, 17 (3), pp.664-674. ⟨10.1039/c8ob02679c⟩. ⟨hal-02503849⟩

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