<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02503849</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-18T23:12:17+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination</title>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Au</surname>
              </persName>
              <idno type="halauthorid">432116-0</idno>
              <affiliation ref="#struct-105319"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christina</forename>
                <surname>Gonzalez</surname>
              </persName>
              <idno type="halauthorid">1715361-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yun Cheuk</forename>
                <surname>Leung</surname>
              </persName>
              <idno type="halauthorid">1715362-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Flora</forename>
                <surname>Mansour</surname>
              </persName>
              <idno type="halauthorid">1715363-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Johny</forename>
                <surname>Trinh</surname>
              </persName>
              <idno type="halauthorid">1715364-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Zhiyong</forename>
                <surname>Wang</surname>
              </persName>
              <idno type="halauthorid">1020296-0</idno>
              <affiliation ref="#struct-463441"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Xiang-Guo</forename>
                <surname>Hu</surname>
              </persName>
              <idno type="halauthorid">1715365-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Renate</forename>
                <surname>Griffith</surname>
              </persName>
              <idno type="halauthorid">1715366-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Eddy</forename>
                <surname>Pasquier</surname>
              </persName>
              <email type="md5">a83e095788751f5676367d3e0a0554e4</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">eddy-pasquier</idno>
              <idno type="idhal" notation="numeric">11270</idno>
              <idno type="halauthorid" notation="string">12935-11270</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2824-5002</idno>
              <idno type="IDREF">https://www.idref.fr/113702590</idno>
              <affiliation ref="#struct-46222"/>
              <affiliation ref="#struct-179570"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Luke</forename>
                <surname>Hunter</surname>
              </persName>
              <idno type="halauthorid">1715367-0</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Stéphanie</forename>
                <surname>BERNARD</surname>
              </persName>
              <email type="md5">ee1dce8bb7fba2047f56472b6fbd6808</email>
              <email type="domain">ipc.unicancer.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-03-10 11:59:26</date>
              <date type="whenModified">2025-05-06 11:02:03</date>
              <date type="whenReleased">2020-03-10 11:59:26</date>
              <date type="whenProduced">2019-01-16</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="855595">
                <persName>
                  <forename>Stéphanie</forename>
                  <surname>BERNARD</surname>
                </persName>
                <email type="md5">ee1dce8bb7fba2047f56472b6fbd6808</email>
                <email type="domain">ipc.unicancer.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02503849</idno>
            <idno type="halUri">https://hal.science/hal-02503849</idno>
            <idno type="halBibtex">au:hal-02503849</idno>
            <idno type="halRefHtml">&lt;i&gt;Organic &amp; Biomolecular Chemistry&lt;/i&gt;, 2019, 17 (3), pp.664-674. &lt;a target="_blank" href="https://dx.doi.org/10.1039/c8ob02679c"&gt;&amp;#x27E8;10.1039/c8ob02679c&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Organic &amp; Biomolecular Chemistry, 2019, 17 (3), pp.664-674. &amp;#x27E8;10.1039/c8ob02679c&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="CRCM">Centre de Recherche en Cancérologie de Marseille</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Au</surname>
                  </persName>
                  <idno type="halauthorid">432116-0</idno>
                  <affiliation ref="#struct-105319"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christina</forename>
                    <surname>Gonzalez</surname>
                  </persName>
                  <idno type="halauthorid">1715361-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yun Cheuk</forename>
                    <surname>Leung</surname>
                  </persName>
                  <idno type="halauthorid">1715362-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Flora</forename>
                    <surname>Mansour</surname>
                  </persName>
                  <idno type="halauthorid">1715363-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Johny</forename>
                    <surname>Trinh</surname>
                  </persName>
                  <idno type="halauthorid">1715364-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Zhiyong</forename>
                    <surname>Wang</surname>
                  </persName>
                  <idno type="halauthorid">1020296-0</idno>
                  <affiliation ref="#struct-463441"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Xiang-Guo</forename>
                    <surname>Hu</surname>
                  </persName>
                  <idno type="halauthorid">1715365-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Renate</forename>
                    <surname>Griffith</surname>
                  </persName>
                  <idno type="halauthorid">1715366-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Eddy</forename>
                    <surname>Pasquier</surname>
                  </persName>
                  <email type="md5">a83e095788751f5676367d3e0a0554e4</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">eddy-pasquier</idno>
                  <idno type="idhal" notation="numeric">11270</idno>
                  <idno type="halauthorid" notation="string">12935-11270</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2824-5002</idno>
                  <idno type="IDREF">https://www.idref.fr/113702590</idno>
                  <affiliation ref="#struct-46222"/>
                  <affiliation ref="#struct-179570"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Luke</forename>
                    <surname>Hunter</surname>
                  </persName>
                  <idno type="halauthorid">1715367-0</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17682</idno>
                <idno type="issn">1477-0520</idno>
                <idno type="eissn">1477-0539</idno>
                <title level="j">Organic &amp; Biomolecular Chemistry</title>
                <imprint>
                  <publisher>Royal Society of Chemistry</publisher>
                  <biblScope unit="volume">17</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">664-674</biblScope>
                  <date type="datePub">2019-01-16</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1039/c8ob02679c</idno>
              <idno type="pubmed">30601550</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Stereoselective fluorination is investigated as a method for modulating the properties of a cyclic RGD-containing tetrapeptide. Three key outcomes of fluorination are assessed: (i) the effect on peptide cyclisation efficiency; (ii) the ability to fine-tune the molecular conformation; and (iii) the effect on the cyclic peptides' biological activity. Fluorination is found to exert pronounced effects against all three criteria.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-105319" status="INCOMING">
          <orgName>Department of Pediatrics</orgName>
          <desc>
            <address>
              <addrLine>Nashville, Tennessee, United States of America</addrLine>
              <country key="US"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-168363" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-463441" status="VALID">
          <idno type="ROR">https://ror.org/012tb2g32</idno>
          <orgName>Tianjin University</orgName>
          <orgName type="acronym">TJU</orgName>
          <date type="start">2016-09-14</date>
          <desc>
            <address>
              <addrLine>92 Weijin Rd, Nankai, Tianjin, Chine, 300072</addrLine>
              <country key="CN"/>
            </address>
            <ref type="url">http://www.tju.edu.cn/english/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-46222" status="OLD">
          <idno type="IdRef">131200550</idno>
          <idno type="RNSR">200816537V</idno>
          <orgName>Centre de Recherches en Oncologie biologique et Oncopharmacologie</orgName>
          <orgName type="acronym">CRO2</orgName>
          <date type="start">2008</date>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine et Faculté de Pharmacie - 27 Boulevard Jean Moulin 13385 Marseille cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cro2-timone.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U911" active="#struct-198056" type="direct"/>
            <relation name="U911" active="#struct-300093" type="direct"/>
            <relation name="U911" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-179570" status="VALID">
          <idno type="RNSR">201220152G</idno>
          <idno type="ROR">0494jpz02</idno>
          <orgName>Centre de Recherche en Cancérologie de Marseille</orgName>
          <orgName type="acronym">CRCM</orgName>
          <date type="start">2012</date>
          <desc>
            <address>
              <addrLine>27 bd Leï Roure, BP 30005913273 Marseille Cedex 09</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://crcm.marseille.inserm.fr/spip.php?article314</ref>
          </desc>
          <listRelation>
            <relation name="UM105" active="#struct-198056" type="direct"/>
            <relation name="UMR7258" active="#struct-301325" type="direct"/>
            <relation active="#struct-301051" type="indirect"/>
            <relation name="U1068" active="#struct-303623" type="direct"/>
            <relation name="UMR7258" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-168363" status="VALID">
          <idno type="ISNI">0000 0001 2159 1389</idno>
          <idno type="ROR">https://ror.org/02vm5rt34</idno>
          <orgName>Vanderbilt University [Nashville]</orgName>
          <desc>
            <address>
              <addrLine>Nashville, Tennessee, TN 37240</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">http://www.vanderbilt.edu/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300093" status="VALID">
          <idno type="ISNI">0000 0001 0404 1115 </idno>
          <idno type="ROR">https://ror.org/05jrr4320</idno>
          <orgName>Hôpital de la Timone [CHU - APHM]</orgName>
          <orgName type="acronym">TIMONE</orgName>
          <date type="start">1974-01-01</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301325" status="VALID">
          <idno type="ROR">https://ror.org/04s3t1g37</idno>
          <orgName>Institut Paoli-Calmettes</orgName>
          <orgName type="acronym">IPC</orgName>
          <desc>
            <address>
              <addrLine>232 Boulevard de Sainte-Marguerite13009 Marseille</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.institutpaolicalmettes.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301051" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301051" status="VALID">
          <orgName>Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>