The way forward for assessing the human health safety of cosmetics in the EU workshop proceedings
Vera Rogiers
(1, 2)
,
Emilio Benfenati
(3)
,
Ulrike Bernauer
(1, 4)
,
Laurent Bodin
(1, 5)
,
Paul Carmichael
(6)
,
Qasim Chaudhry
(1, 7)
,
Pieter Jan Coenraads
(1, 8)
,
Mark T.D. Cronin
(9)
,
Matthew Dent
(6)
,
Maria Dusinska
(1, 10)
,
Corie Ellison
(11)
,
Janine Ezendam
(1, 12)
,
Eric Gaffet
(13, 1)
,
Corrado Lodovico Galli
(1, 14)
,
Carsten Goebel
,
Berit Granum
(1, 15)
,
Heli Miriam Hollnagel
(16)
,
Petra Kern
(11)
,
Kirstin Kosemund-Meynen
,
Gladys Ouédraogo
(17)
,
Eirini Panteri
(1, 18)
,
Christophe Rousselle
(1, 19)
,
Maciej Stepnik
(1, 20)
,
Tamara Vanhaecke
(1, 2)
,
Natalie von Goetz
(21)
,
Andrew Worth
(22)
1
SCCS -
Scientific Committee for Consumer Safety (SCCS)
2 VUB - Vrije Universiteit Brussel [Bruxelles]
3 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research
4 BfR - Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment
5 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
6 Unilever-Safety & Environmental Assurance Centre
7 University of Chester
8 UMCG - University Medical Center Groningen [Groningen]
9 LJMU - Liverpool John Moores University
10 NILU - Norsk Institutt for Luftforskning
11 P&G - Procter & Gamble
12 RIVM - National Institute for Public Health and the Environment [Bilthoven]
13 IJL - Institut Jean Lamour
14 UNIMI - Università degli Studi di Milano = University of Milan
15 NIPH - Norwegian Institute of Public Health [Oslo]
16 Dow Europe GmbH
17 L'Oréal Recherche - L'Oréal Recherche France
18 NKUA - National and Kapodistrian University of Athens
19 DER - Direction de l'Evaluation des Risques
20 NIOM - Nofer Institute of Occupational Medicine
21 Swiss Federal Office of Public Health
22 JRC - European Commission - Joint Research Centre [Ispra]
2 VUB - Vrije Universiteit Brussel [Bruxelles]
3 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" = Mario Negri Institute for Pharmacological Research
4 BfR - Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment
5 CEA - Commissariat à l'énergie atomique et aux énergies alternatives
6 Unilever-Safety & Environmental Assurance Centre
7 University of Chester
8 UMCG - University Medical Center Groningen [Groningen]
9 LJMU - Liverpool John Moores University
10 NILU - Norsk Institutt for Luftforskning
11 P&G - Procter & Gamble
12 RIVM - National Institute for Public Health and the Environment [Bilthoven]
13 IJL - Institut Jean Lamour
14 UNIMI - Università degli Studi di Milano = University of Milan
15 NIPH - Norwegian Institute of Public Health [Oslo]
16 Dow Europe GmbH
17 L'Oréal Recherche - L'Oréal Recherche France
18 NKUA - National and Kapodistrian University of Athens
19 DER - Direction de l'Evaluation des Risques
20 NIOM - Nofer Institute of Occupational Medicine
21 Swiss Federal Office of Public Health
22 JRC - European Commission - Joint Research Centre [Ispra]
Laurent Bodin
- Fonction : Auteur
- PersonId : 766153
- ORCID : 0000-0002-6900-8874
Qasim Chaudhry
- Fonction : Auteur
- PersonId : 896185
Pieter Jan Coenraads
- Fonction : Auteur
- PersonId : 781694
- ORCID : 0000-0001-9458-7129
Eric Gaffet
- Fonction : Auteur
- PersonId : 13168
- IdHAL : eric-gaffet
- ORCID : 0000-0002-6451-3011
- IdRef : 096415258
Carsten Goebel
- Fonction : Auteur
Kirstin Kosemund-Meynen
- Fonction : Auteur
Eirini Panteri
- Fonction : Auteur
- PersonId : 781621
- ORCID : 0000-0003-3190-0127
Christophe Rousselle
- Fonction : Auteur
- PersonId : 1133111
- ORCID : 0000-0003-0460-6192
- IdRef : 147122341
Maciej Stepnik
- Fonction : Auteur
- PersonId : 781695
- ORCID : 0000-0003-1586-2482
Tamara Vanhaecke
- Fonction : Auteur
- PersonId : 766074
- ORCID : 0000-0002-6685-7299
Natalie von Goetz
- Fonction : Auteur
- PersonId : 799888
- ORCID : 0000-0001-5257-4573
Andrew Worth
- Fonction : Auteur
- PersonId : 762270
- ORCID : 0000-0002-5303-0452
Résumé
Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This means that for the safety assessment of cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called "Replacement methods". In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of "New Approach Methodology" that could be useful tools in the context of the "Next Generation Risk Assessment" and the strategic framework for safety assessment of cosmetics were discussed in depth.