Enhancement of hydrosolubility and in vitro antiproliferative properties of chalcones following encapsulation into β-cyclodextrin/cellulose-nanocrystal complexes
Résumé
This paper describes the preparation of two chalcone/β-cyclodextrin/cellulose-nanocrystals complexes and thestudy of their antiproliferative activities against two colorectal and two prostatic cancer cell lines. The aim of thiswork was to enhance hydrosolubility of chalcones thanks to the hydrophilic character of cellulose nanocrystals.These latter were linked, through ionic interactions, to a cationic derivative of β-cyclodextrins whose lipophiliccavity allowed the encapsulation of hydrophobic chalcones: 3-hydroxy-3′,4,4′,5′-tetramethoxychalcone (1) and3′,4,4′,5′-tetramethoxychalcone (2). First, we showed that encapsulation allowed hydrosolubilization of chalcones.Then, chalcone/β-cyclodextrin/cellulose-nanocrystals complexes demonstrated enhanced in vitro antiproliferativeactivities, compared to the corresponding free-chalcones.
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