Comparative genomics applied to Mucor species with different lifestyles - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue BMC Genomics Année : 2020

Comparative genomics applied to Mucor species with different lifestyles

Annie Lebreton
Erwan Corre
Jean-Luc Jany
  • Fonction : Auteur
  • PersonId : 1036140
Loraine Brillet-Guéguen
Carlos Pèrez-Arques
  • Fonction : Auteur
Victoriano Garre
  • Fonction : Auteur
Misharl Monsoor
  • Fonction : Auteur
Christophe Le Meur
  • Fonction : Auteur
Emmanuel Coton
  • Fonction : Auteur
Georges Barbier
  • Fonction : Auteur
Laurence Meslet-Cladière
  • Fonction : Auteur

Résumé

BACKGROUND: Despite a growing number of investigations on early diverging fungi, the corresponding lineages have not been as extensively characterized as Ascomycota or Basidiomycota ones. The Mucor genus, pertaining to one of these lineages is not an exception. To this date, a restricted number of Mucor annotated genomes is publicly available and mainly correspond to the reference species, Mucor circinelloides, and to medically relevant species. However, the Mucor genus is composed of a large number of ubiquitous species as well as few species that have been reported to specifically occur in certain habitats. The present study aimed to expand the range of Mucor genomes available and identify potential genomic imprints of adaptation to different environments and lifestyles in the Mucor genus. RESULTS: In this study, we report four newly sequenced genomes of Mucor isolates collected from non-clinical environments pertaining to species with contrasted lifestyles, namely Mucor fuscus and Mucor lanceolatus, two species used in cheese production (during ripening), Mucor racemosus, a recurrent cheese spoiler sometimes described as an opportunistic animal and human pathogen, and Mucor endophyticus, a plant endophyte. Comparison of these new genomes with those previously available for six Mucor and two Rhizopus (formerly identified as M. racemosus) isolates allowed global structural and functional description such as their TE content, core and species-specific genes and specialized genes. We proposed gene candidates involved in iron metabolism; some of these genes being known to be involved in pathogenicity; and described patterns such as a reduced number of CAZymes in the species used for cheese ripening as well as in the endophytic isolate that might be related to adaptation to different environments and lifestyles within the Mucor genus. CONCLUSIONS: This study extended the descriptive data set for Mucor genomes, pointed out the complexity of obtaining a robust phylogeny even with multiple genes families and allowed identifying contrasting potentially lifestyle-associated gene repertoires. The obtained data will allow investigating further the link between genetic and its biological data, especially in terms of adaptation to a given habitat.
Fichier principal
Vignette du fichier
Lebreton2020_Article_ComparativeGenomicsAppliedToMu.pdf (3.24 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02481326 , version 1 (10-11-2020)

Licence

Paternité

Identifiants

Citer

Annie Lebreton, Erwan Corre, Jean-Luc Jany, Loraine Brillet-Guéguen, Carlos Pèrez-Arques, et al.. Comparative genomics applied to Mucor species with different lifestyles. BMC Genomics, 2020, 21 (1), pp.135. ⟨10.1186/s12864-019-6256-2⟩. ⟨hal-02481326⟩
38 Consultations
47 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More