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Journal Articles Antimicrobial Agents and Chemotherapy Year : 2020

Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against Mycobacterium abscessus

Abstract

New drugs or therapeutic combinations are urgently needed against Mycobacterium abscessus Previously, we demonstrated the potent activity of indole-2-carboxamides 6 and 12 against M. abscessus. We show here that these compounds act synergistically with imipenem and cefoxitin in vitro and increase the bactericidal activity of the β-lactams against M. abscessus In addition, compound 12 also displays synergism with imipenem and cefoxitin within infected macrophages. The clinical potential of these new drug combinations requires further evaluation.
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Dates and versions

hal-02479144 , version 1 (22-06-2020)

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Clement Raynaud, Wassim Daher, Françoise Roquet-Banères, Matt Johansen, Jozef Stec, et al.. Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, 2020, [Epub ahead of print] (5), pp.AAC.02548-19. ⟨10.1128/AAC.02548-19⟩. ⟨hal-02479144⟩
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