Metastasis and the evolution of dispersal - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the Royal Society B: Biological Sciences Année : 2019

Metastasis and the evolution of dispersal

Résumé

Despite significant progress in oncology, metastasis remains the leading cause of mortality of cancer patients. Understanding the foundations of this phenomenon could help contain or even prevent it. As suggested by many ecologists and cancer biologists, metastasis could be considered through the lens of biological dispersal: the movement of cancer cells from their birth site (the primary tumour) to other habitats where they resume proliferation (metastatic sites). However, whether this model can consistently be applied to the emergence and dynamics of metastasis remains unclear. Here, we provide a broad review of various aspects of the evolution of dispersal in ecosystems. We investigate whether similar ecological and evolutionary principles can be applied to metastasis, and how these processes may shape the spatio-temporal dynamics of disseminating cancer cells. We further discuss complementary hypotheses and propose experimental approaches to test the relevance of the evolutionary ecology of dispersal in studying metastasis.
Fichier principal
Vignette du fichier
Tissot et al. - 2019 - Proceedings of the Royal Society Series B.pdf (649.09 Ko) Télécharger le fichier
Origine Publication financée par une institution
Licence
Loading...

Dates et versions

hal-02461792 , version 1 (04-02-2020)

Licence

Identifiants

Citer

Tazzio Tissot, Francois Massol, Beata Ujvari, Catherine Alix-Panabières, Nicolas Loeuille, et al.. Metastasis and the evolution of dispersal. Proceedings of the Royal Society B: Biological Sciences, 2019, 286 (1916), pp.20192186. ⟨10.1098/rspb.2019.2186⟩. ⟨hal-02461792⟩
100 Consultations
74 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More