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Article Dans Une Revue Journal of Solution Chemistry Année : 2020

Solubilities and Crystallization of Olanzapine Using a Multi‑Well Setup: The Effect of Solvents and Cooling Rates

Résumé

The use of a multi-well system allowed us to measure the solubility of two anhydrous forms of olanzapine in pure solvents with different polarities in a temperature range of 20 to 60° Celsius (°C) with a small quantity of material. After that, we carried out cooling crystallization experiments in a stagnant medium with a small volume of 0.8 mL and a small quantity of material. We found that the solubility increased with the solvent polarity in the order: methanol> ethanol > acetonitrile > ethyl acetate > tetrahydrofuran > toluene. We demonstrated the effect of the solvents and the cooling rates on the crystal habit, crystal phase, and crystal size distribution.
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Dates et versions

hal-02445258 , version 1 (20-01-2020)

Identifiants

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N Guemras, Kamel Daoud, S. Veesler. Solubilities and Crystallization of Olanzapine Using a Multi‑Well Setup: The Effect of Solvents and Cooling Rates. Journal of Solution Chemistry, 2020, 49, pp.1170-1185. ⟨10.1007/s10953-020-01019-6⟩. ⟨hal-02445258⟩
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