Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review - Archive ouverte HAL
Article Dans Une Revue (Article De Synthèse) Clinical Nutrition Année : 2020

Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review

1 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
2 Unipd - Università degli Studi di Padova = University of Padua
3 Universität Heidelberg [Heidelberg] = Heidelberg University
4 University of Hohenheim
5 Service Nutrition Clinique [CHU Clermont-Ferrand]
6 UNH - Unité de Nutrition Humaine
7 Uppsala University
8 IRYCIS - Instituto Ramón y Cajal de Investigación Sanitaria
9 Sackler Faculty of Medicine
10 TAU - Tel Aviv University
11 IdiSNA - Instituto de Investigacion Sanitaria de Navarra
12 Universidad de Navarra (Pamplona)
13 CIBEROBN - Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición - Biomedical Research Center in Red-Physiopathology of Obesity and Nutrition
14 University Hospital
15 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]
16 UCPEL - Catholic University of Pelotas
17 SNUBH - Seoul National University Bundang Hospital
18 Pennington Biomedical Research Center
19 Fujita Health University
20 University of Alberta
21 University of Navarra
22 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
23 Gérontopôle
24 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
25 University of Pisa - Università di Pisa
26 UON - University of Nottingham, UK
27 Peking Union Medical College
28 UNIVR - Università degli studi di Verona = University of Verona
29 Università degli studi di Trieste = University of Trieste

Résumé

Background Sarcopenic obesity is a clinical and functional condition characterized by the coexistence of excess fat mass and sarcopenia. Currently, different definitions of sarcopenic obesity exist and its diagnostic criteria and cut-offs are not universally established. Therefore, the prevalence and sensitivity of this condition for any disease risk prediction is affected significantly. Aim This work was conducted under the auspices of the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO). An international expert panel performed a systematic review as an initial step to analyze and summarize the available scientific literature on the definitions and the diagnostic criteria for sarcopenic obesity proposed and/or applied in human studies to date. Methods The present systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The search was conducted in April 2018 in three databases (PubMed, Scopus, Web of Science). Human studies conducted in both sexes, irrespective of ethnicity, and published from 2007 to 2018 were included; cohorts of individuals with obesity and acute or chronic conditions and treatments reported to negatively influence skeletal muscle mass and function independently of obesity were excluded from final analyses. The quality of the studies was evaluated using the Newcastle–Ottawa Scale (NOS) adapted for cross sectional studies. Results The electronic search retrieved 2335 papers of which 75 met the eligibility criteria. A marked heterogeneity in definitions and approaches to diagnose sarcopenic obesity was observed. This was mainly due to differences in the definitions of obesity and sarcopenia, in the methodologies used to assess body composition and physical function, and in the reference values for the variables that have been used (different cut-offs, interquartile analysis, diverse statistical stratification methods). This variability may be attributable, at least in part, to the availability of the methodologies in the different settings, to the variability in specialties and backgrounds of the researcher, and to the different settings (general population, clinical settings, etc.) where studies were performed. Conclusion The results of the current work support the need for consensus proposals on: 1) definition of sarcopenic obesity; 2) diagnostic criteria both at the level of potential gold-standards and acceptable surrogates with wide clinical applicability, and with related cut-off values; 3) methodologies to be used in actions 1 and 2. First steps should be aimed at reaching consensus on plausible proposals that would need subsequent validation based on homogeneous studies and databases, possibly based on analyses of existing cohorts, to help define the prevalence of the condition, its clinical and functional relevance as well as most effective prevention and treatment strategies.

Dates et versions

hal-02441504 , version 1 (15-01-2020)

Identifiants

Citer

Lorenzo M. Donini, Luca Busetto, Juergen M. Bauer, Stephan Bischoff, Yves Boirie, et al.. Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review. Clinical Nutrition, 2020, ⟨10.1016/j.clnu.2019.11.024⟩. ⟨hal-02441504⟩
149 Consultations
0 Téléchargements

Altmetric

Partager

More