Non-Genetic Determinants of Mosquito Competence for Malaria Parasites - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS Pathogens Année : 2013

Non-Genetic Determinants of Mosquito Competence for Malaria Parasites

Résumé

Understanding how mosquito vectors and malaria parasites interact is of fundamental interest, and it also offers novel perspectives for disease control. Both the genetic and environmental contexts are known to affect the ability of mosquitoes to support malaria development and transmission, i.e., vector competence. Although the role of environment has long been recognized, much work has focused on host and parasite genetic effects. However, the last few years have seen a surge of studies revealing a great diversity of ways in which non-genetic factors can interfere with mosquito-Plasmodium interactions. Here, we review the current evidence for such environmentally mediated effects, including ambient temperature, mosquito diet, microbial gut flora, and infection history, and we identify additional factors previously overlooked in mosquito-Plasmodium interactions. We also discuss epidemiological implications, and the evolutionary consequences for vector immunity and parasite transmission strategies. Finally, we propose directions for further research and argue that an improved knowledge of non-genetic influences on mosquito-Plasmodium interactions could aid in implementing conventional malaria control measures and contribute to the design of novel strategies.
Fichier principal
Vignette du fichier
non_genetic_determinants_of_mosquito_competence.PDF (3.03 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02411036 , version 1 (16-12-2019)

Licence

Paternité

Identifiants

Citer

Thierry Lefèvre, Amélie Vantaux, Kounbobr Roch Dabiré, Karine Mouline, Anna Cohuet. Non-Genetic Determinants of Mosquito Competence for Malaria Parasites. PLoS Pathogens, 2013, 9 (6), pp.e1003365. ⟨10.1371/journal.ppat.1003365⟩. ⟨hal-02411036⟩
37 Consultations
39 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More