Brain metastases from non-small cell lung carcinoma: Changing concepts for improving patients’ outcome - Archive ouverte HAL
Article Dans Une Revue Crit.Rev.Oncol.Hematol. Année : 2017

Brain metastases from non-small cell lung carcinoma: Changing concepts for improving patients’ outcome

Chloé Rancoule
  • Fonction : Auteur
Alexis Vallard
  • Fonction : Auteur
Sophie Espenel
  • Fonction : Auteur
Peng Diao
  • Fonction : Auteur
Cyrus Chargari
  • Fonction : Auteur
Nicolas Magné
  • Fonction : Auteur
  • PersonId : 936917
  • IdRef : 05352862X

Résumé

The management of Non Small Cell Lung Cancer (NSCLC) brain metastases is challenging, as this frequent complication negatively impacts patients’ quality of life, and can be a life-threatening event. Through a review of the literature, we discuss the main therapeutic options and the recent developments that improved (and complicated) the management of NSCLC brain metastases patients. Most current validated approaches are local with exclusive or combined surgery, whole brain radiotherapy (WBRT) and stereotactic radiotherapy (SRT). At the same time, there is a growing role for systemic treatments that might significantly postpone WBRT. Targeted therapies efficacy/toxicity profile remains to be defined but predictive and prognostic molecular factors integration could help to select treatments fully adapted to life expectancy and progression risk.
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Dates et versions

hal-02404404 , version 1 (11-12-2019)

Identifiants

Citer

Chloé Rancoule, Alexis Vallard, Jean-Baptiste Guy, Sophie Espenel, Peng Diao, et al.. Brain metastases from non-small cell lung carcinoma: Changing concepts for improving patients’ outcome. Crit.Rev.Oncol.Hematol., 2017, 116, pp.32-37. ⟨10.1016/j.critrevonc.2017.05.007⟩. ⟨hal-02404404⟩
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