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Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2019

Improvements of C–H Radio-Iodination of N-Acylsulfonamides toward Implementation in Clinics

Résumé

An improved protocol to perform C–H radio-iodination is described. These new conditions allow rapid and clean formation of radio-iodinated N-acylsulfonamides using [125I]NIS and catalytic amounts of palladium acetate and para-toluenesulfonic acid. No pre-functionalized precursors are required and the products are obtained with radiochemical conversions (RCC) of 27–84%.

Domaines

Radiochimie
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Dates et versions

hal-02400013 , version 1 (09-12-2019)

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Citer

Emmanuelle Dubost, Victor Babin, Florian Benoist, Alexandra Hébert, Gilbert Pigrée, et al.. Improvements of C–H Radio-Iodination of N-Acylsulfonamides toward Implementation in Clinics. Synthesis: Journal of Synthetic Organic Chemistry, 2019, 51 (23), pp.4393-4400. ⟨10.1055/s-0037-1611884⟩. ⟨hal-02400013⟩
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