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Article Dans Une Revue Acta Neuropsychiatrica Année : 2019

Differential semantic processing in patients with schizophrenia versus bipolar disorder: an N400 study

Résumé

OBJECTIVE: Both bipolar disorder (BD) and schizophrenia (SZ) are associated with language and thought symptoms that probably reflect a semantic memory-related impairment. We conducted a preliminary study to explore the nature of semantic processing in these disorders, using event-related potentials (ERPs). METHODS: Twelve patients with BD, 10 patients with SZ and a matched group of 21 healthy controls (HC) underwent EEG recording while they heard sentences containing homophones or control words and performed a semantic ambiguity resolution task on congruent or incongruent targets. RESULTS: Mean N400 amplitude differed between groups for homophones. Patients with SZ made more resolution errors than HC and exhibited a greater N400 congruity effect in ambiguous conditions than BD. In BD, the opposite N400 congruity effect was observed in ambiguous conditions. CONCLUSION: Results indicated differences in semantic processing between BD and SZ. Further studies with larger populations are needed in order to develop neurophysiological markers of these disorders.
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Dates et versions

hal-02397444 , version 1 (06-12-2019)

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D. Raucher-Chéné, Sarah Terrien, P. Gobin, F. Gierski, Stéphanie Caillies, et al.. Differential semantic processing in patients with schizophrenia versus bipolar disorder: an N400 study. Acta Neuropsychiatrica, 2019, 31 (6), pp.337-342. ⟨10.1017/neu.2019.9⟩. ⟨hal-02397444⟩

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