Ni/Photoredox-Dual-Catalyzed Functionalization of 1-Thiosugars
Résumé
A general protocol for functionalization of glycosyl thiols has been reported. This protocol is based on a single-electron Ni/photoredox dual-catalyzed cross-coupling between 1-thiosugars and a broad range of arylbromides and iodides as well as alkenyl and alkynyl halides. This base-free method gives access to a series of functionalized thioglycosides in moderate to excellent yields with a perfect control of the anomeric configuration. Moreover, it has been shown that this methodology may be transposed successfully to the continuous-flow photoredox chemistry.
Domaines
Catalyse| Origine | Fichiers produits par l'(les) auteur(s) |
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