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Communication Dans Un Congrès Année : 2019

Toward the creation of 2D or 3D clusters of cells in acoustic levitation

Résumé

Introduction Today, three-dimensional (3D) cell cultures tend to replace 2D conventional method because of their more relevant tissue-mimicking characteristics. Indeed, the 3D cell architecture (spheroïd, organoïd, etc) and the microenvironment is closer to In Vivo physiological behaviour [1, 2]. The main difficulties remain in creating a scaffold compatible with the targeted cells and tissues. Bioprinting is one the great objective for tissue engineering. For instance, stereolithography is a 3D printing technology where the freestanding object is built layer by layer with a photosensitive polymer resin through the projection of a UV image in the top plane. In recent promising work, stereolithography has been applied to create 3D hydrogel structures to guide cells like hepatocytes [3]. Nevertheless, ideally, scaffold-free methods are needed. We propose a new method combining microfluidic channels and the acoustic radiation force (ARF) to structure and to control the shape of stem-cells aggregates.
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Dates et versions

hal-02395236 , version 1 (05-12-2019)

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  • HAL Id : hal-02395236 , version 1

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Nathan Jeger-Madiot, Niclas Setterblad, Lousineh Arakelian, Valérie Vanneaux, Mauricio Hoyos, et al.. Toward the creation of 2D or 3D clusters of cells in acoustic levitation. AcoustoFluidics 2019, Aug 2019, Enschede, Netherlands. ⟨hal-02395236⟩
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