Microdialysis Unveils the Role of the α 2 -Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ACS Chemical Neuroscience Année : 2019

Microdialysis Unveils the Role of the α 2 -Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat

Résumé

Previous work has shown that β-adrenergic and GABAergic systems in the basolateral amygdala (BLA) are involved in the acquisition of conditioned odor aversion (COA) learning. The involvement of α 2adrenoreceptors, however, is poorly documented. In a first experiment, male Long-Evans rats received infusions of 0.1 μg of the selective α 2antagonist dexefaroxan (Dex) in the BLA before being exposed to COA learning. In a second experiment, levels of norepinephrine (NE) were analyzed following Dex retrodialysis into the BLA. While microdialysis data showed a significant enhancement of NE release in the BLA with Dex, behavioral results showed that pre-CS infusion of Dex impaired, rather than facilitated, the acquisition of COA. Our results show that the NE system in the BLA is involved in the acquisition of COA, including a strong α 2-receptor modulation until now unsuspected. Supported by the recent literature, the present data suggest moreover that the processes underlying this learning are probably mediated by the balanced effects of NE excitatory/inhibitory signaling in the BLA, in which interneurons are highly involved.
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hal-02395084 , version 1 (12-10-2021)

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Lucile Estrade, Jean-Christophe Cassel, Sandrine Parrot, Patricia Duchamp-Viret, Barbara Ferry. Microdialysis Unveils the Role of the α 2 -Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat. ACS Chemical Neuroscience, 2019, 10 (4), pp.1929-1934. ⟨10.1021/acschemneuro.8b00314⟩. ⟨hal-02395084⟩
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