Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Physiology - Paris Année : 2007

Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro.

Résumé

In humans, several pathologies are associated with disturbances of the respiratory control, some of them including alteration in the brain-derived neurotrophic factor (BDNF) signalling pathway. BDNF has long been known as a neurotrophic factor involved in survival, differentiation and maintenance of neuronal populations in the peripheral and central nervous system. More recently BDNF has also been discovered to be a potent neuromodulator with acute effects on neuronal excitability and synaptic plasticity. Animals deleted for the gene encoding BDNF exhibit respiratory alteration suggesting an important but yet undefined role of the neurotrophin in respiratory rhythmogenesis either by a trophic and/or an acute action. The possibility that BDNF might exert an acute regulatory role on the rhythmic activity of the respiratory generator of the pre-B?nger complex has been recently examined in newborn mice in vitro. Results obtained, reviewed in the present paper, will help getting insights in respiratory rhythm regulatory mechanisms that involve BDNF signalling.

Dates et versions

hal-02394562 , version 1 (04-12-2019)

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Julien Bouvier, Sandra Autran, Gilles Fortin, Jean Champagnat, Muriel Thoby-Brisson. Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro.. Journal of Physiology - Paris, 2007, 100 (5-6), pp.290-6. ⟨10.1016/j.jphysparis.2007.05.008⟩. ⟨hal-02394562⟩

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